Favara B E, Jaffe R
Department of Pathology and Laboratory Medicine, All Children's Hospital, St. Petersburg, FL 33701.
Br J Cancer Suppl. 1994 Sep;23:S17-23.
Selected aspects of the histopathology of Langerhans cell histiocytosis representing diagnostic difficulty and/or controversy are presented with emphasis on the composition of pathological lesions. Lesional cell phenotypes and the factors influencing variations are noted. Features of several skin-based histiocytic disorders, dermatopathic lymphadenopathy and Rosai-Dorfman disease are compared. Associations between Langerhans cell histiocytosis and juvenile xanthogranuloma and malignant disorders are considered. Observations of potential significance in the eventual elucidation of the pathogenesis of these enigmatic diseases are presented.
本文介绍了朗格汉斯细胞组织细胞增多症组织病理学中存在诊断困难和/或争议的特定方面,重点在于病理病变的组成。记录了病变细胞表型及影响变异的因素。比较了几种皮肤组织细胞疾病、皮肤性淋巴结病和罗萨伊-多夫曼病的特征。探讨了朗格汉斯细胞组织细胞增多症与幼年性黄色肉芽肿及恶性疾病之间的关联。还介绍了在最终阐明这些疑难疾病发病机制方面可能具有重要意义的观察结果。