• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Helping daughters succeed: asymmetric distribution of glucose transporter mRNA.帮助女儿成功：葡萄糖转运体 mRNA 的不对称分布。
EMBO J. 2019 May 15;38(10). doi: 10.15252/embj.2019102063. Epub 2019 Apr 29.
2
Asymmetric distribution of glucose transporter mRNA provides a growth advantage in yeast.葡萄糖转运蛋白 mRNA 的非对称分布为酵母提供了生长优势。
EMBO J. 2019 May 15;38(10). doi: 10.15252/embj.2018100373. Epub 2019 Mar 25.
3
Characterization of the effectiveness of hexose transporters for transporting xylose during glucose and xylose co-fermentation by a recombinant Saccharomyces yeast.重组酿酒酵母在葡萄糖和木糖共发酵过程中己糖转运蛋白转运木糖的有效性表征
Yeast. 2004 Jun;21(8):671-84. doi: 10.1002/yea.1060.
4
Sugar consumption and ethanol fermentation by transporter-overexpressed xylose-metabolizing Saccharomyces cerevisiae harboring a xyloseisomerase pathway.通过过表达转运蛋白的酵母摄取糖和乙醇发酵利用木糖代谢途径中的木糖异构酶。
J Biosci Bioeng. 2012 Aug;114(2):209-11. doi: 10.1016/j.jbiosc.2012.03.004. Epub 2012 May 15.
5
Allelic variants of hexose transporter Hxt3p and hexokinases Hxk1p/Hxk2p in strains of Saccharomyces cerevisiae and interspecies hybrids.酿酒酵母菌株及种间杂种中己糖转运蛋白Hxt3p和己糖激酶Hxk1p/Hxk2p的等位基因变体。
Yeast. 2015 Nov;32(11):657-69. doi: 10.1002/yea.3087. Epub 2015 Sep 1.
6
Spontaneous mutations that confer resistance to 2-deoxyglucose act through Hxk2 and Snf1 pathways to regulate gene expression and HXT endocytosis.自发突变赋予了对 2-脱氧葡萄糖的抗性，通过 Hxk2 和 Snf1 途径调节基因表达和 HXT 内吞作用。
PLoS Genet. 2020 Jul 16;16(7):e1008484. doi: 10.1371/journal.pgen.1008484. eCollection 2020 Jul.
7
Saccharomyces cerevisiae and metabolic activators: HXT3 gene expression and fructose/glucose discrepancy in sluggish fermentation conditions.酿酒酵母与代谢激活剂：在发酵迟缓条件下HXT3基因表达及果糖/葡萄糖差异
World J Microbiol Biotechnol. 2016 Dec;32(12):196. doi: 10.1007/s11274-016-2154-9. Epub 2016 Oct 12.
8
2-Deoxyglucose impairs Saccharomyces cerevisiae growth by stimulating Snf1-regulated and α-arrestin-mediated trafficking of hexose transporters 1 and 3.2-脱氧葡萄糖通过刺激Snf1调节的和α- Arrestin介导的己糖转运蛋白1和3的转运来损害酿酒酵母的生长。
Mol Cell Biol. 2015 Mar;35(6):939-55. doi: 10.1128/MCB.01183-14. Epub 2014 Dec 29.
9
In vivo regulation of glucose transporter genes at glucose concentrations between 0 and 500 mg/L in a wild type of Saccharomyces cerevisiae.在野生型酿酒酵母中，葡萄糖浓度在0至500毫克/升之间时对葡萄糖转运蛋白基因的体内调控。
J Biotechnol. 2008 Jun 1;135(2):161-7. doi: 10.1016/j.jbiotec.2008.03.009. Epub 2008 Mar 29.
10
Characterisation of glucose transport in Saccharomyces cerevisiae with plasma membrane vesicles (countertransport) and intact cells (initial uptake) with single Hxt1, Hxt2, Hxt3, Hxt4, Hxt6, Hxt7 or Gal2 transporters.利用单种Hxt1、Hxt2、Hxt3、Hxt4、Hxt6、Hxt7或Gal2转运蛋白，通过质膜囊泡（反向转运）和完整细胞（初始摄取）对酿酒酵母中的葡萄糖转运进行表征。
FEMS Yeast Res. 2002 Dec;2(4):539-50. doi: 10.1111/j.1567-1364.2002.tb00121.x.

本文引用的文献

1
Asymmetric distribution of glucose transporter mRNA provides a growth advantage in yeast.葡萄糖转运蛋白 mRNA 的非对称分布为酵母提供了生长优势。
EMBO J. 2019 May 15;38(10). doi: 10.15252/embj.2018100373. Epub 2019 Mar 25.
2
AMPK-Mediated Regulation of Alpha-Arrestins and Protein Trafficking.AMPK 介导的 α-抑制蛋白和蛋白转运调控。
Int J Mol Sci. 2019 Jan 25;20(3):515. doi: 10.3390/ijms20030515.
3
2-Deoxyglucose impairs Saccharomyces cerevisiae growth by stimulating Snf1-regulated and α-arrestin-mediated trafficking of hexose transporters 1 and 3.2-脱氧葡萄糖通过刺激Snf1调节的和α- Arrestin介导的己糖转运蛋白1和3的转运来损害酿酒酵母的生长。
Mol Cell Biol. 2015 Mar;35(6):939-55. doi: 10.1128/MCB.01183-14. Epub 2014 Dec 29.
4
Scp160-dependent mRNA trafficking mediates pheromone gradient sensing and chemotropism in yeast.SCP160 依赖性 mRNA 运输介导线粒体感知和酵母的化学趋向性。
Cell Rep. 2012 May 31;1(5):483-94. doi: 10.1016/j.celrep.2012.03.004. Epub 2012 Apr 20.
5
Cotranslational transport of ABP140 mRNA to the distal pole of S. cerevisiae.ABP140mRNA 共翻译转运至酿酒酵母远端极。
EMBO J. 2011 Jul 26;30(17):3567-80. doi: 10.1038/emboj.2011.247.
6
mRNA localization: gene expression in the spatial dimension.mRNA定位：空间维度上的基因表达。
Cell. 2009 Feb 20;136(4):719-30. doi: 10.1016/j.cell.2009.01.044.
7
mRNAs encoding polarity and exocytosis factors are cotransported with the cortical endoplasmic reticulum to the incipient bud in Saccharomyces cerevisiae.在酿酒酵母中，编码极性和胞吐作用因子的信使核糖核酸（mRNAs）与皮质内质网共同运输至初始芽体。
Mol Cell Biol. 2007 May;27(9):3441-55. doi: 10.1128/MCB.01643-06. Epub 2007 Mar 5.
8
Std1 and Mth1 proteins interact with the glucose sensors to control glucose-regulated gene expression in Saccharomyces cerevisiae.Std1和Mth1蛋白与葡萄糖传感器相互作用，以控制酿酒酵母中葡萄糖调节的基因表达。
Mol Cell Biol. 1999 Jul;19(7):4561-71. doi: 10.1128/MCB.19.7.4561.
9
Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast.酵母中编码细胞命运决定因子的RNA的肌动蛋白依赖性定位。
Nature. 1997 Sep 4;389(6646):90-3. doi: 10.1038/38015.
10
Mating type switching in yeast controlled by asymmetric localization of ASH1 mRNA.酵母中的交配型转换由ASH1 mRNA的不对称定位控制。
Science. 1997 Jul 18;277(5324):383-7. doi: 10.1126/science.277.5324.383.

帮助女儿成功：葡萄糖转运体 mRNA 的不对称分布。

Helping daughters succeed: asymmetric distribution of glucose transporter mRNA.

机构信息

Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, PA, USA.

出版信息

EMBO J. 2019 May 15;38(10). doi: 10.15252/embj.2019102063. Epub 2019 Apr 29.

DOI:10.15252/embj.2019102063
PMID:31036552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6517811/
Abstract

Rapidly proliferating cells growing by glucose fermentation must first transport glucose into the cell. Both budding yeast and human tumor cells utilize members of a conserved family of glucose transporters. In this issue of , Stahl (2019) reveal that budding yeast cells confer a growth advantage to their daughters using a novel mechanism, the asymmetric distribution to the daughter cell of the mRNA for a specific glucose transporter.

摘要

快速增殖的细胞通过葡萄糖发酵生长，必须首先将葡萄糖运输到细胞内。出芽酵母和人类肿瘤细胞都利用一组保守的葡萄糖转运蛋白家族成员。在本期的《细胞》杂志中，Stahl （2019）揭示了出芽酵母细胞通过一种新的机制将特定葡萄糖转运蛋白的 mRNA 不对称地分配到子细胞中，从而赋予其女儿细胞生长优势。