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甲状腺侦探:追寻孟乔森综合征

Thyroid detectives: on the trail of Munchausen's syndrome.

作者信息

Chakraborty Partha Pratim, Goswami Soumik, Bhattacharjee Rana, Chowdhury Subhankar

机构信息

Endocrinology and Metabolism, Medical College, Kolkata, West Bengal, India.

Endocrinology, Nil Ratan Sircar Medical College, Kolkata, West Bengal, India.

出版信息

BMJ Case Rep. 2019 Apr 29;12(4):e226087. doi: 10.1136/bcr-2018-226087.

DOI:10.1136/bcr-2018-226087
PMID:31036731
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6506104/
Abstract

Thyrotoxicosis factitia, a disorder frequently seen in young or middle-aged women with psychological disorders, most commonly results from surreptitious ingestion of excess thyroid hormones. In most patients, diagnosis is relatively straightforward and depends on the demonstration of biochemical thyrotoxicosis, suppressed endogenous thyroid function and absence of clinical features of underlying thyroid disease. However, at times, confounding factors can make the diagnosis particularly challenging and necessitate the investigating physician to don the detective's cap to get to the root of the problem. We discuss a patient whose diagnosis was reached with ingenuity after considerable effort from four endocrinologists having a total experience of 37 years in their field.

摘要

人为性甲状腺毒症常见于患有心理障碍的中青年女性,多由偷偷过量摄入甲状腺激素所致。多数患者的诊断相对简单,依据生化性甲状腺毒症、内源性甲状腺功能受抑制以及无潜在甲状腺疾病的临床特征来确诊。然而,有时一些混杂因素会使诊断极具挑战性,这就需要负责调查的医生像侦探一样去探寻问题的根源。我们将讨论这样一位患者,在四位内分泌科医生总计37年的专业经验下,经过一番努力才巧妙地做出诊断。

相似文献

1
Thyroid detectives: on the trail of Munchausen's syndrome.甲状腺侦探:追寻孟乔森综合征
BMJ Case Rep. 2019 Apr 29;12(4):e226087. doi: 10.1136/bcr-2018-226087.
2
Color flow Doppler sonography in thyrotoxicosis factitia.人为甲状腺毒症的彩色多普勒超声检查
J Endocrinol Invest. 1996 Oct;19(9):603-6. doi: 10.1007/BF03349025.
3
Thyroid color flow doppler sonography and radioiodine uptake in 55 consecutive patients with amiodarone-induced thyrotoxicosis.对55例连续的胺碘酮所致甲状腺毒症患者进行甲状腺彩色多普勒超声检查及放射性碘摄取检查。
J Endocrinol Invest. 2003 Jul;26(7):635-40. doi: 10.1007/BF03347021.
4
Color-flow Doppler sonography in the differential diagnosis and management of amiodarone-induced thyrotoxicosis.彩色多普勒超声在胺碘酮所致甲状腺毒症鉴别诊断及处理中的应用
Acta Radiol. 2007 Jul;48(6):628-34. doi: 10.1080/02841850701342138.
5
DSM-III differential diagnosis of Munchausen's syndrome.
J Nerv Ment Dis. 1980 Oct;168(10):629-32.
6
Thyroid vascularity and blood flow are not dependent on serum thyroid hormone levels: studies in vivo by color flow doppler sonography.甲状腺血管分布及血流并不依赖于血清甲状腺激素水平:彩色多普勒超声体内研究
Eur J Endocrinol. 1999 May;140(5):452-6. doi: 10.1530/eje.0.1400452.
7
Munchausen's syndrome and other factitious disorders.孟乔森综合征及其他做作性障碍。
Neurol Clin. 1995 May;13(2):267-81.
8
Munchausen's syndrome: a medico-legal dilemma.
Med Sci Law. 1997 Jul;37(3):198-201. doi: 10.1177/002580249703700303.
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The age of patients with thyrotoxicosis factitia in Italy from 1973 to 1996.1973年至1996年意大利人为性甲状腺毒症患者的年龄情况。
J Endocrinol Invest. 1999 Feb;22(2):128-33. doi: 10.1007/BF03350892.
10
Diagnosis and management of amiodarone-induced thyrotoxicosis in Europe: results of an international survey among members of the European Thyroid Association.欧洲胺碘酮所致甲状腺毒症的诊断与管理:欧洲甲状腺协会成员的一项国际调查结果
Clin Endocrinol (Oxf). 2004 Oct;61(4):494-502. doi: 10.1111/j.1365-2265.2004.02119.x.

本文引用的文献

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False-positive radioiodine uptake in a functional ovarian cyst in a patient treated with total thyroidectomy for papillary cancer.一名因乳头状癌接受全甲状腺切除术的患者,其功能性卵巢囊肿出现放射性碘摄取假阳性。
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Thyrotoxicosis factitia masquerading as recurrent Graves' disease: endogenous antibody immunoassay interference, a pitfall for the unwary.伪装成复发性格雷夫斯病的人为甲状腺毒症:内源性抗体免疫测定干扰,粗心者的陷阱。
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Thyroglobulin autoantibody levels below the cut-off for positivity can interfere with thyroglobulin measurement.低于阳性临界值的甲状腺球蛋白自身抗体水平可能会干扰甲状腺球蛋白的测量。
Thyroid. 2003 Jul;13(7):659-61. doi: 10.1089/105072503322240013.
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The age of patients with thyrotoxicosis factitia in Italy from 1973 to 1996.1973年至1996年意大利人为性甲状腺毒症患者的年龄情况。
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Hypothyroidism as a late sequela in patient with Graves' disease treated with antithyroid agents.甲状腺功能减退症作为接受抗甲状腺药物治疗的格雷夫斯病患者的晚期后遗症。
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