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低于阳性临界值的甲状腺球蛋白自身抗体水平可能会干扰甲状腺球蛋白的测量。

Thyroglobulin autoantibody levels below the cut-off for positivity can interfere with thyroglobulin measurement.

作者信息

Cubero J M, Rodríguez-Espinosa J, Gelpi C, Estorch M, Corcoy R

机构信息

Serveis d'Endocrinologia i Nutrició, Hospital de Sant Pau, Barcelona, Spain.

出版信息

Thyroid. 2003 Jul;13(7):659-61. doi: 10.1089/105072503322240013.

DOI:10.1089/105072503322240013
PMID:12964972
Abstract

Antithyroglobulin antibodies can interfere with the measurement of thyroglobulin yielding spuriously high or low levels depending on the method used. Interference is unrelated to the antibody concentration and can occur at very low concentrations. We report a patient in whom antithyroglobulin antibodies below the cut-off for positivity nearly led to an incorrect diagnosis of thyrotoxicosis factitia.

摘要

抗甲状腺球蛋白抗体可干扰甲状腺球蛋白的检测,根据所使用的方法,会产生假性的高值或低值。干扰与抗体浓度无关,在极低浓度时也可能发生。我们报告了一名患者,其抗甲状腺球蛋白抗体低于阳性临界值,几乎导致人为甲状腺毒症的误诊。

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