Séhonou Jean, Kpossou Aboudou Raïmi, Amanda Taofick Oyétoundé, Sokpon Comlan N'dehougbea Martin, Vignon Rodolph Koffi, Vigan Jacques
Clinique Universitaire d'Hépato-Gastroentérologie, Centre National Hospitalier et Universitaire Hubert Koutoukou Maga (CNHU-HKM), Cotonou, Bénin.
Faculté des Sciences de la Santé (FSS), Université d'Abomey-Calavi, Bénin.
Pan Afr Med J. 2018 Oct 17;31:121. doi: 10.11604/pamj.2018.31.121.16498. eCollection 2018.
the association between the kidneys and hepatitis B is complex. This study aims to determine the prevalence and factors associated with renal disease in people living with hepatitis B virus (PLHBV) in Cotonou.
we conducted a cross-sectional, descriptive and analytical study in the Hepatogastroenterology Department at the National University Hospital Center in Cotonou over the period May -August 2017. All the patients with positive hepatitis B surface antigen (HBS Ag) test hospitalized in the study period were included. The diagnosis of renal failure was retained in patients with glomerular filtration rate less than 90 mL/min/1.73 m (estimated with MDRD Equation).
the study involved 105 patients with positive hepatitis B surface antigen (HBS Ag) test Among them, 65 (61.9%) were under anti-HBV treatment ( 62 of them were under tenofovir ); 41 patients had renal failure (39%) with tubular involvement (2 cases) and glomerular involvement (4 cases). Renal function had got progressively worse over time in 22 patients (21%) and had improved in 6 patients (5.7%). Univariate analysis showed that factors associated with the occurrence of renal failure were: age greater than 50 years (p = 0.0125), high blood pressure (p = 0.0037), initially abnormal renal function (p < 0.0003) and co-medications (p = 0.0007). Anti-HBV treatment wasn't associated with the occurrence of renal failure (p = 0.2887).
the prevalence of renal failure in PLHBV was high (39%). Age, arterial hypertension, pre-existing renal failure and co-medications were identified as factors associated with decline in renal function in PLHBV.
肾脏与乙型肝炎之间的关联很复杂。本研究旨在确定科托努地区乙型肝炎病毒感染者（PLHBV）中肾病的患病率及相关因素。
2017年5月至8月期间，我们在科托努国立大学医院中心的胃肠肝病科进行了一项横断面、描述性和分析性研究。纳入研究期间住院且乙肝表面抗原（HBS Ag）检测呈阳性的所有患者。肾小球滤过率低于90 mL/（min/1.73 m²）（用MDRD方程估算）的患者被诊断为肾衰竭。
该研究纳入了105例乙肝表面抗原（HBS Ag）检测呈阳性的患者。其中，65例（61.9%）正在接受抗HBV治疗（其中62例接受替诺福韦治疗）；41例患者出现肾衰竭（39%），伴有肾小管受累（2例）和肾小球受累（4例）。22例患者（21%）的肾功能随时间逐渐恶化，6例患者（5.7%）的肾功能有所改善。单因素分析显示，与肾衰竭发生相关的因素有：年龄大于50岁（p = 0.0125）、高血压（p = 0.0037）、初始肾功能异常（p < 0.0003）和联合用药（p = 0.0007）。抗HBV治疗与肾衰竭的发生无关（p = 0.2887）。
PLHBV中肾衰竭的患病率很高（39%）。年龄、动脉高血压、既往存在的肾衰竭和联合用药被确定为与PLHBV肾功能下降相关的因素。
