氯喹对正常人和非胰岛素依赖型糖尿病患者胰岛素及葡萄糖稳态的影响。
Effect of chloroquine on insulin and glucose homoeostasis in normal subjects and patients with non-insulin-dependent diabetes mellitus.
作者信息
Smith G D, Amos T A, Mahler R, Peters T J
出版信息
Br Med J (Clin Res Ed). 1987 Feb 21;294(6570):465-7. doi: 10.1136/bmj.294.6570.465.
Abstract
Plasma glucose, insulin, and C peptide concentrations were determined after an oral glucose load in normal subjects and in a group of patients with non-insulin-dependent diabetes mellitus before and during a short course of treatment with chloroquine. In the control group there was a small but significant reduction in fasting blood glucose concentration but overall glucose tolerance and hormone concentrations were unaffected. In contrast, the patients with non-insulin-dependent diabetes mellitus showed a significant improvement in their glucose tolerance, which paralleled the severity of their diabetes. This response seems to reflect decreased degradation of insulin rather than increased pancreatic output. These observations suggest that treatment with chloroquine or suitable analogues may be a new approach to the management of diabetes.
摘要
在正常受试者以及一组非胰岛素依赖型糖尿病患者口服葡萄糖负荷后，测定了血浆葡萄糖、胰岛素和C肽浓度，这些患者在接受短疗程氯喹治疗之前和治疗期间进行了上述测定。在对照组中，空腹血糖浓度有小幅但显著的降低，但总体葡萄糖耐量和激素浓度未受影响。相比之下，非胰岛素依赖型糖尿病患者的葡萄糖耐量有显著改善，这与他们糖尿病的严重程度平行。这种反应似乎反映了胰岛素降解减少而非胰腺分泌增加。这些观察结果表明，用氯喹或合适的类似物治疗可能是糖尿病管理的一种新方法。
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