Winter Elizabeth Martha, Schrander-van der Meer Anita, Eustatia-Rutten Carmen, Janssen Martien
Department of Internal Medicine, Rijnland Hospital Leiderdorp, Leiderdorp, Netherlands.
BMJ Case Rep. 2011 Oct 28;2011:bcr0620114393. doi: 10.1136/bcr.06.2011.4393.
The authors report a remarkable glucose lowering side effect of the often used drug hydroxychloroquine (Plaquenil) in an otherwise healthy non-diabetic patient, who presented with severe hypoglycaemia. Although the mechanism has not been clarified yet, increased insulin sensitivity as well as decreased insulin degradation is suggested to contribute to the reduction in serum glucose levels. Clinicians prescribing this drug must be warranted and check glucose levels in the initial phase. Moreover, hydroxychloroquine might be applied as therapeutic in refractory diabetic rheumatics or rheumatic patients at risk to develop diabetes mellitus.
作者报告了常用药物羟氯喹（羟氯喹啉）在一名原本健康的非糖尿病患者中出现的显著降糖副作用，该患者出现了严重低血糖。尽管其机制尚未明确，但胰岛素敏感性增加以及胰岛素降解减少被认为有助于降低血糖水平。开具此药的临床医生必须谨慎，并在初始阶段检查血糖水平。此外，羟氯喹可用于治疗难治性糖尿病性风湿病患者或有患糖尿病风险的风湿性疾病患者。
