• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

循环生物活性肾上腺髓质素预测脓毒症器官衰竭和死亡。

Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis.

机构信息

Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.

Sphingotec GmbH, Hennigsdorf, Germany.

出版信息

Ann Lab Med. 2019 Sep;39(5):454-463. doi: 10.3343/alm.2019.39.5.454.

DOI:10.3343/alm.2019.39.5.454
PMID:31037864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6502946/
Abstract

BACKGROUND

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Biologically active adrenomedullin (bio-ADM) is an emerging biomarker for sepsis. We explored whether bio-ADM concentration could predict severity, organ failure, and 30-day mortality in septic patients.

METHODS

In 215 septic patients (109 patients with sepsis; 106 patients with septic shock), bio-ADM concentration was measured at diagnosis of sepsis, using sphingotest bio-ADM (Sphingotec GmbH, Hennigsdorf, Germany) and analyzed in terms of sepsis severity, vasopressor use, and 30-day mortality. The number of organ failures, sequential (sepsis-related) organ failure assessment (SOFA) score, and 30-day mortality were compared according to bio-ADM quartiles.

RESULTS

Bio-ADM concentration was significantly higher in patients with septic shock, vasopressor use, and non-survivors than in patients with solitary sepsis, no vasopressor use, and survivors, respectively (all <0.0001). Bio-ADM quartiles were associated with the number of organ failures (<0.0001), as well as SOFA cardiovascular, renal, coagulation, and liver subscores (all <0.05). The 30-day mortality rate showed a stepwise increase in each bio-ADM quartile (all <0.0001). Bio-ADM concentration and SOFA score equally predicted the 30-day mortality (area under the curve: 0.827 vs 0.830).

CONCLUSIONS

Bio-ADM could serve as a useful and objective biomarker to predict severity, organ failure, and 30-day mortality in septic patients.

摘要

背景

败血症是一种危及生命的器官功能障碍，由宿主对感染的失调反应引起。生物活性肾上腺髓质素（bio-ADM）是败血症的一个新兴生物标志物。我们探讨了 bio-ADM 浓度是否可以预测败血症患者的严重程度、器官衰竭和 30 天死亡率。

方法

在 215 例败血症患者（109 例败血症患者；106 例败血症性休克患者）中，使用 Sphingotest bio-ADM（Sphingotec GmbH，德国亨尼希多夫）在败血症诊断时测量 bio-ADM 浓度，并根据败血症严重程度、血管加压素使用情况和 30 天死亡率进行分析。根据 bio-ADM 四分位数比较器官衰竭数量、序贯（与败血症相关的）器官衰竭评估（SOFA）评分和 30 天死亡率。

结果

败血症性休克、血管加压素使用和非幸存者的 bio-ADM 浓度明显高于单独败血症、无血管加压素使用和幸存者（均<0.0001）。bio-ADM 四分位数与器官衰竭数量相关（<0.0001），以及 SOFA 心血管、肾脏、凝血和肝脏亚评分（均<0.05）。30 天死亡率在每个 bio-ADM 四分位数中呈阶梯式增加（均<0.0001）。bio-ADM 浓度和 SOFA 评分同样可以预测 30 天死亡率（曲线下面积：0.827 对 0.830）。

结论

bio-ADM 可以作为一种有用和客观的生物标志物，预测败血症患者的严重程度、器官衰竭和 30 天死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f62/6502946/dfd8810b8f70/alm-39-454-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f62/6502946/77da46fca146/alm-39-454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f62/6502946/32c95f4dceb1/alm-39-454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f62/6502946/5e90d6beb0b3/alm-39-454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f62/6502946/dfd8810b8f70/alm-39-454-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f62/6502946/77da46fca146/alm-39-454-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f62/6502946/32c95f4dceb1/alm-39-454-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f62/6502946/5e90d6beb0b3/alm-39-454-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f62/6502946/dfd8810b8f70/alm-39-454-g004.jpg

相似文献

1
Circulating Biologically Active Adrenomedullin Predicts Organ Failure and Mortality in Sepsis.循环生物活性肾上腺髓质素预测脓毒症器官衰竭和死亡。
Ann Lab Med. 2019 Sep;39(5):454-463. doi: 10.3343/alm.2019.39.5.454.
2
Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study.循环肾上腺髓质素评估脓毒症器官衰竭的存活和可逆性：前瞻性观察性多国肾上腺髓质素和脓毒症及脓毒性休克-1 结局研究（AdrenOSS-1）。
Crit Care. 2018 Dec 21;22(1):354. doi: 10.1186/s13054-018-2243-2.
3
Circulating Biologically Active Adrenomedullin (bio-ADM) Predicts Hemodynamic Support Requirement and Mortality During Sepsis.循环生物活性肾上腺髓质素（生物活性ADM）可预测脓毒症期间的血流动力学支持需求和死亡率。
Chest. 2017 Aug;152(2):312-320. doi: 10.1016/j.chest.2017.03.035. Epub 2017 Apr 12.
4
Proenkephalin Predicts Organ Failure, Renal Replacement Therapy, and Mortality in Patients With Sepsis.脑啡肽原预测脓毒症患者的器官衰竭、肾脏替代治疗和死亡率。
Ann Lab Med. 2020 Nov;40(6):466-473. doi: 10.3343/alm.2020.40.6.466. Epub 2020 Jun 17.
5
Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness.循环生物活性肾上腺髓质素作为脓毒症、脓毒性休克和危重病的标志物。
Crit Care. 2020 Nov 4;24(1):636. doi: 10.1186/s13054-020-03351-1.
6
Procalcitonin and MR-Proadrenomedullin Combination with SOFA and qSOFA Scores for Sepsis Diagnosis and Prognosis: A Diagnostic Algorithm.降钙素原和 MR 前肾上腺髓质素联合 SOFA 和 qSOFA 评分对脓毒症的诊断和预后：一种诊断算法。
Shock. 2018 Jul;50(1):44-52. doi: 10.1097/SHK.0000000000001023.
7
[The study on pro-adrenomedullin as a new biomarker in sepsis prognosis and risk stratification].[促肾上腺髓质素作为脓毒症预后和风险分层新生物标志物的研究]
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2008 Aug;20(8):452-5.
8
[The value of pro-adrenomedullin in early diagnosis of sepsis].[前肾上腺髓质素在脓毒症早期诊断中的价值]
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Sep;27(9):739-42.
9
Plasma adrenomedullin is associated with short-term mortality and vasopressor requirement in patients admitted with sepsis.脓毒症入院患者的血浆肾上腺髓质素与短期死亡率及血管升压药需求相关。
Crit Care. 2014 Feb 17;18(1):R34. doi: 10.1186/cc13731.
10
MR- proADM to detect specific types of organ failure in infection.MR-proADM 用于检测感染中的特定类型的器官衰竭。
Eur J Clin Invest. 2020 Jun;50(6):e13246. doi: 10.1111/eci.13246. Epub 2020 May 19.

引用本文的文献

1
Bio-Adrenomedullin and Dipeptidyl Peptidase 3 as Novel Sepsis Biomarkers in the Emergency Department and the Intensive Care Unit: A Narrative Review.生物肾上腺髓质素和二肽基肽酶3作为急诊科和重症监护病房新型脓毒症生物标志物的叙述性综述
Medicina (Kaunas). 2025 Jun 9;61(6):1059. doi: 10.3390/medicina61061059.
2
Optical Bionanosensors for Sepsis Diagnostics.用于脓毒症诊断的光学生物纳米传感器
Small. 2025 Feb;21(8):e2409042. doi: 10.1002/smll.202409042. Epub 2025 Jan 2.
3
Bioactive Adrenomedullin in Dogs with Sepsis and Septic Shock: A Prospective, Case-Control Study.

本文引用的文献

1
Sandwich Immunoassay for Bioactive Plasma Adrenomedullin.生物活性血浆肾上腺髓质素的夹心免疫测定法
J Appl Lab Med. 2017 Sep 1;2(2):222-233. doi: 10.1373/jalm.2017.023655.
2
Bio-adrenomedullin as a marker of congestion in patients with new-onset and worsening heart failure.生物肾上腺髓质素作为新发和恶化心力衰竭患者充血的标志物。
Eur J Heart Fail. 2019 Jun;21(6):732-743. doi: 10.1002/ejhf.1437. Epub 2019 Mar 6.
3
A double-blind, placebo-controlled, randomised, multicentre, proof-of-concept and dose-finding phase II clinical trial to investigate the safety, tolerability and efficacy of adrecizumab in patients with septic shock and elevated adrenomedullin concentration (AdrenOSS-2).
脓毒症和脓毒性休克犬体内的生物活性肾上腺髓质素：一项前瞻性病例对照研究。
Animals (Basel). 2024 Oct 23;14(21):3054. doi: 10.3390/ani14213054.
4
Utility of Adrenomedullin in Predicting Outcomes in Patients with Acute Febrile Illness in the Tropics: A Prospective Observational Study.肾上腺髓质素在预测热带地区急性发热性疾病患者预后中的作用：一项前瞻性观察研究。
Am J Trop Med Hyg. 2024 Oct 8;111(6):1338-1342. doi: 10.4269/ajtmh.24-0301. Print 2024 Dec 4.
5
Navigating the Modern Landscape of Sepsis: Advances in Diagnosis and Treatment.脓毒症的现代诊治策略：进展与挑战。
Int J Mol Sci. 2024 Jul 5;25(13):7396. doi: 10.3390/ijms25137396.
6
Postoperative bioactive adrenomedullin is associated with the onset of ARDS and adverse outcomes in patients undergoing open thoracoabdominal aortic surgery.术后生物活性肾上腺髓质素与开胸胸腹主动脉手术后患者 ARDS 的发生和不良预后相关。
Sci Rep. 2024 Jun 4;14(1):12795. doi: 10.1038/s41598-024-63412-1.
7
The 'analysis of gene expression and biomarkers for point-of-care decision support in Sepsis' study; temporal clinical parameter analysis and validation of early diagnostic biomarker signatures for severe inflammation andsepsis-SIRS discrimination.用于脓毒症即时决策支持的基因表达和生物标志物分析研究；严重炎症和脓毒症-全身炎症反应综合征鉴别诊断的即时临床参数分析和早期诊断生物标志物特征验证。
Front Immunol. 2024 Jan 25;14:1308530. doi: 10.3389/fimmu.2023.1308530. eCollection 2023.
8
Use of Biomarkers to Improve 28-Day Mortality Stratification in Patients with Sepsis and SOFA ≤ 6.使用生物标志物改善脓毒症且序贯器官衰竭评估（SOFA）评分≤6分患者的28天死亡率分层
Biomedicines. 2023 Jul 30;11(8):2149. doi: 10.3390/biomedicines11082149.
9
Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial Pneumonia in the Emergency Department.在急诊科，测量循环生物肾上腺髓质素和 proenkephalin 对 COVID-19 和非 COVID-19 间质性肺炎患者 30 天死亡率风险预测的效用。
Medicina (Kaunas). 2022 Dec 15;58(12):1852. doi: 10.3390/medicina58121852.
10
Effects of enrichment strategies on outcome of adrecizumab treatment in septic shock: analyses of the phase II adrenomedullin and outcome in septic shock 2 trial.富集策略对脓毒性休克患者接受阿祖单抗治疗结局的影响：II期肾上腺髓质素与脓毒性休克2试验结局分析
Front Med (Lausanne). 2022 Dec 1;9:1058235. doi: 10.3389/fmed.2022.1058235. eCollection 2022.
一项旨在研究阿地珠单抗在脓毒性休克伴高肾上腺髓质素浓度（AdrenOSS-2）患者中的安全性、耐受性和疗效的双盲、安慰剂对照、随机、多中心、概念验证和剂量探索的 II 期临床试验。
BMJ Open. 2019 Feb 19;9(2):e024475. doi: 10.1136/bmjopen-2018-024475.
4
Adrenomedullin in heart failure: pathophysiology and therapeutic application.心力衰竭中的肾上腺髓质素：病理生理学和治疗应用。
Eur J Heart Fail. 2019 Feb;21(2):163-171. doi: 10.1002/ejhf.1366. Epub 2018 Dec 28.
5
Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study.循环肾上腺髓质素评估脓毒症器官衰竭的存活和可逆性：前瞻性观察性多国肾上腺髓质素和脓毒症及脓毒性休克-1 结局研究（AdrenOSS-1）。
Crit Care. 2018 Dec 21;22(1):354. doi: 10.1186/s13054-018-2243-2.
6
The Septic Heart: Current Understanding of Molecular Mechanisms and Clinical Implications.脓毒症性心脏病：分子机制的现有认识及临床意义。
Chest. 2019 Feb;155(2):427-437. doi: 10.1016/j.chest.2018.08.1037. Epub 2018 Aug 29.
7
Bio-adrenomedullin as a potential quick, reliable, and objective marker of congestion in heart failure.生物肾上腺髓质素作为心力衰竭中充血的一种潜在快速、可靠且客观的标志物。
Eur J Heart Fail. 2018 Sep;20(9):1363-1365. doi: 10.1002/ejhf.1245. Epub 2018 Jun 22.
8
Review article: Sepsis in the emergency department - Part 3: Treatment.综述文章：急诊科脓毒症——第3部分：治疗
Emerg Med Australas. 2018 Apr;30(2):144-151. doi: 10.1111/1742-6723.12951.
9
The use of mid-regional proadrenomedullin to identify disease severity and treatment response to sepsis - a secondary analysis of a large randomised controlled trial.使用中肾上腺髓质原(proadrenomedullin)来识别脓毒症的严重程度和治疗反应 - 一项大型随机对照试验的二次分析。
Crit Care. 2018 Mar 21;22(1):79. doi: 10.1186/s13054-018-2001-5.
10
Adrenomedullin and Adrenomedullin-Targeted Therapy As Treatment Strategies Relevant for Sepsis.肾上腺髓质素和肾上腺髓质素靶向治疗作为脓毒症相关的治疗策略。
Front Immunol. 2018 Feb 19;9:292. doi: 10.3389/fimmu.2018.00292. eCollection 2018.