类风湿关节炎患者肠道通透性增加：口服非甾体抗炎药治疗的副作用？

Increased intestinal permeability in patients with rheumatoid arthritis: a side-effect of oral nonsteroidal anti-inflammatory drug therapy?

作者信息

Jenkins R T, Rooney P J, Jones D B, Bienenstock J, Goodacre R L

出版信息

Br J Rheumatol. 1987 Apr;26(2):103-7. doi: 10.1093/rheumatology/26.2.103.

DOI:10.1093/rheumatology/26.2.103

Abstract

Intestinal permeability in controls and in patients with active rheumatoid arthritis was assessed by measuring the radioactivity in 24-h urine collections after oral administration of 51Cr-EDTA. Intestinal permeability in the patients was found to be significantly increased in comparison to controls. Of the patients, 6/7 (86%) not taking any prescribed nonsteroidal anti-inflammatory drug (NSAID) at the time of study had normal results, whereas 23/29 patients (79%) taking prescribed NSAIDs displayed increased intestinal permeability. It has not been determined beyond doubt whether this finding is due to disease process or therapy with oral NSAIDs.

摘要

通过口服51Cr-EDTA后测量24小时尿液收集物中的放射性，评估了对照组和活动性类风湿关节炎患者的肠道通透性。与对照组相比，发现患者的肠道通透性显著增加。在研究时未服用任何处方非甾体抗炎药（NSAID）的患者中，7例中有6例（86%）结果正常，而服用处方NSAIDs的29例患者中有23例（79%）显示肠道通透性增加。这一发现究竟是由于疾病过程还是口服NSAIDs治疗所致，尚未得到确凿的定论。