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[Demonstration of an oxidative biotransformation of 9-methoxyellipticine. Comparison with the case of 9-hydroxyellipticine].

作者信息

Braham Y, Meunier G, Meunier B

出版信息

C R Acad Sci III. 1987;304(11):301-6.

PMID:3103875
Abstract

Evidences for the formation of the glutathione-hydroxyellipticine adduct during the rat metabolism of 9-methoxyellipticine are provided. These data suggest that such a cytotoxic molecule might behave as a pro-alkylating agent in vivo.

摘要

相似文献

1
[Demonstration of an oxidative biotransformation of 9-methoxyellipticine. Comparison with the case of 9-hydroxyellipticine].
C R Acad Sci III. 1987;304(11):301-6.
2
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Metabolism of the anti-tumour drugs N2-methyl-9-hydroxyellipticinium acetate (NSC 264137) and N2-methyl-9-hydroxyolivacinium acetate in the rat: preliminary identification of biliary 9-(O)-glucuronide and 10-(S)-glutathione conjugates.
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