Microbial transformations of natural antitumor agents. VIII. Formation of 8- and 9-hydroxyellipticines.
作者信息
Chien M M, Rosazza J P
出版信息
Drug Metab Dispos. 1979 Jul-Aug;7(4):211-4.
PMID:39722
Abstract
Microbial transformations of ellipticine with Aspergillus alliaceus (NRRL 315) yielded two phenolic metabolites which were isolated and characterized as 8- and 9-hydroxyellipticines. The latter is a major metabolite and its structure was determined by NMR and mass-spectometric analyses, and by comparison with authentic 9-hydroxyellipticine prepared by chemical demethylation of 9-methoxyellipticine. The structure of 8-hydroxyellipticine was determined primarily by NMR spectrometry. Whereas 8-hydroxyellipticine is a new derivative, 9-hydroxyellipticine has been described, and it is one of the major mammalian metabolites of the antitumor alkaloid ellipticine.
摘要
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Microbial transformations of natural antitumor agents. VIII. Formation of 8- and 9-hydroxyellipticines.
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