按类型划分的咖啡摄入量与消化道癌症风险：一项大型前瞻性队列研究。
Coffee consumption by type and risk of digestive cancer: a large prospective cohort study.
机构信息
Cancer Epidemiology Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK.
Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, Northern Ireland, UK.
出版信息
Br J Cancer. 2019 May;120(11):1059-1066. doi: 10.1038/s41416-019-0465-y. Epub 2019 May 1.
BACKGROUND
Inverse associations have been observed between coffee consumption and liver cancer, but associations for other digestive cancers are unclear. Few previous studies have investigated coffee type (specifically instant or ground coffee) or a range of digestive cancer types within one cohort. We therefore investigated coffee consumption by type and digestive cancer risks in a population-based cohort.
METHODS
The UK Biobank captured self-reported coffee consumption and cancer-registry recorded incident digestive cancers. Hazard ratios (HRs) and 95% CIs were calculated using Cox regression. The risk of every type of digestive cancer was investigated in association with coffee consumption by dose-response and by coffee type (decaffeinated, instant and ground).
RESULTS
Over 7.5 years of follow-up, 3567 developed digestive cancer among 471,779 participants. There were 88 cases of hepatocellular carcinoma and a marked association was observed for hepatocellular carcinoma in coffee drinkers (HR 0.50, 95% CI 0.29, 0.87), which was similar for instant (HR 0.51, 95% CI 0.28, 0.93) and ground coffee (HR 0.47, 95% CI 0.20, 1.08). We did not observe significant consistently reduced risks of other individual digestive cancers amongst coffee drinkers.
CONCLUSIONS
We found some evidence that coffee consumption was inversely associated with hepatocellular carcinoma which was similar by coffee type.
背景
已有研究表明，咖啡的摄入与肝癌呈负相关，但咖啡与其他消化道癌的关系尚不清楚。先前的研究大多集中于咖啡的种类（即速溶咖啡或研磨咖啡）或某一种消化道癌，而很少有研究在一个队列中调查咖啡的种类和多种消化道癌的发病风险。因此，我们在一个基于人群的队列中调查了不同种类的咖啡消费与消化道癌风险之间的关系。
方法
英国生物库收集了自我报告的咖啡摄入量和癌症登记处记录的新发消化道癌病例。使用 Cox 回归计算风险比（HR）和 95%置信区间（CI）。通过剂量反应和咖啡种类（无因、速溶和研磨），研究了每种消化道癌与咖啡消费之间的关联。
结果
在 7.5 年的随访期间，471779 名参与者中有 3567 人患上了消化道癌。其中 88 例为肝细胞癌，咖啡饮用者的肝癌发病风险明显降低（HR 0.50，95%CI 0.29,0.87），速溶咖啡（HR 0.51，95%CI 0.28,0.93）和研磨咖啡（HR 0.47，95%CI 0.20,1.08）的结果与之相似。我们没有观察到咖啡饮用者中其他个别消化道癌的风险显著降低。
结论
我们发现了一些证据表明，咖啡的摄入与肝细胞癌呈负相关，而且这种相关性在不同咖啡种类之间是相似的。
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