Li Mengqi, Wang Weihan, Zhang Lin, Xin Wenqiang, Zhao Yan, Huan Linchun, Yu Jianjun, Zhang Hao, Zhang Jianning, Yang Shuyuan, Liang Degang, Yang Weidong, Yang Xinyu
Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China,
Key Laboratory of Post-Neurotrauma Neurorepair and Regeneration in Central Nervous System, Ministry of Education in China and Tianjin, Tianjin Neurological Institute, Tianjin, People's Republic of China,
Neuropsychiatr Dis Treat. 2019 Apr 2;15:779-783. doi: 10.2147/NDT.S193478. eCollection 2019.
Genetic factors play a vital role in intracranial aneurysm (IA) onset and development. Studying the relationship between IA and the polymorphisms in diverse populations is essential for establishing credibility.
We collected blood samples derived from a total of 596 sporadic IA patients and 600 individual controls in several medical institutes in China. We used the Sequenom MassArray system for single nucleotide polymorphisms (SNPs) genotyping after DNA extraction. The SNPs data was tested and analyzed in PLINK (version 1.9). Multiple-testing was performed in PLINK to make the statistics more rigorous and accurate.
We found that the allelic G of rs1072737 (OR=1.303, genomic-control corrected -value =0.001032) is a risk allele, while the allelic G of rs9298506 (OR=0.7253, genomic-control corrected -value =0.01559) is a protective allele in Chinese Han people.
The allelic G of rs1072737 is a risk factor for IA, while the allelic G of rs9298506 serves as a protective factor for IA in Chinese Han people.
遗传因素在颅内动脉瘤（IA）的发生和发展中起着至关重要的作用。研究IA与不同人群基因多态性之间的关系对于确立其可信度至关重要。
我们在中国的几家医疗机构收集了总共596例散发性IA患者和600例个体对照的血样。DNA提取后，我们使用Sequenom MassArray系统进行单核苷酸多态性（SNP）基因分型。SNP数据在PLINK（版本1.9）中进行测试和分析。在PLINK中进行多重检验以使统计更加严谨和准确。
我们发现，在中国汉族人群中，rs1072737的等位基因G（OR = 1.303，基因组对照校正P值= 0.001032）是一个风险等位基因，而rs9298506的等位基因G（OR = 0.7253，基因组对照校正P值= 0.01559）是一个保护等位基因。
在中国汉族人群中，rs1072737的等位基因G是IA的一个风险因素，而rs9298506的等位基因G是IA的一个保护因素。
