可变蛋白酶敏感性朊蛋白病：痴呆的鉴别诊断考量
Variably protease-sensitive prionopathy: A differential diagnostic consideration for dementia.
作者信息
Kim Stella H, Yu Melissa M, Strutt Adriana M
机构信息
Baylor College of Medicine, Houston, TX.
出版信息
Neurol Clin Pract. 2019 Apr;9(2):145-151. doi: 10.1212/CPJ.0000000000000612.
PURPOSE OF REVIEW
Prion diseases are rare neurodegenerative diseases that are caused by abnormal pathogenic agents and can affect both humans and animals. These diseases are categorized as sporadic, inherited, or acquired by infection. Clinical manifestations include psychiatric symptoms, cognitive impairment, and parkinsonism, which are similar to those of other prion diseases and frontotemporal dementia variants.
RECENT FINDINGS
More recently, scientists discovered a new sporadic prion disease called variably protease-sensitive prionopathy.
SUMMARY
The following case discusses a patient presenting with sudden onset and rapid decline in cognitive, neurobehavioral, and motor functioning and his clinical journey including treatment interventions and diagnostic confirmation.
综述目的
朊病毒病是由异常病原体引起的罕见神经退行性疾病，可影响人类和动物。这些疾病分为散发性、遗传性或感染性。临床表现包括精神症状、认知障碍和帕金森综合征，与其他朊病毒病和额颞叶痴呆变体相似。
最新发现
最近，科学家发现了一种新的散发性朊病毒病，称为可变蛋白酶敏感性朊病毒病。
总结
以下病例讨论了一名患者，其出现认知、神经行为和运动功能突然发作并迅速衰退，以及他的临床历程，包括治疗干预和诊断确认。
Zotero 插件