重组鼠γ干扰素对荚膜组织胞浆菌细胞内生长的抑制作用。
Inhibition of the intracellular growth of Histoplasma capsulatum by recombinant murine gamma interferon.
作者信息
Wu-Hsieh B A, Howard D H
出版信息
Infect Immun. 1987 Apr;55(4):1014-6. doi: 10.1128/iai.55.4.1014-1016.1987.
Abstract
Recombinant murine gamma interferon as well as lymphokines prepared from immune splenocytes and concanavalin A-stimulated T-cell hybridoma activated normal mouse peritoneal macrophages to inhibit the intracellular growth of Histoplasma capsulatum. The activities of the lymphokine from immune splenocytes and of recombinant murine gamma interferon were neutralized by rabbit anti-murine gamma interferon antibody. The intracellular yeasts were not killed by the interaction even though growth was completely inhibited.
摘要
重组鼠γ干扰素以及从免疫脾细胞和伴刀豆球蛋白A刺激的T细胞杂交瘤制备的淋巴因子可激活正常小鼠腹腔巨噬细胞，以抑制荚膜组织胞浆菌的细胞内生长。来自免疫脾细胞的淋巴因子和重组鼠γ干扰素的活性被兔抗鼠γ干扰素抗体中和。即使生长被完全抑制，细胞内酵母也不会因这种相互作用而被杀死。
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