Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.
Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA.
Cell Host Microbe. 2024 Oct 9;32(10):1681-1690. doi: 10.1016/j.chom.2024.09.011.
Fungal disease poses a growing threat to public health that our current antifungal therapies are not well equipped to meet. As the population of immunocompromised hosts expands, and ecological changes favor the emergence of fungal pathogens, the development of new antifungal agents, including vaccines, becomes a global priority. Here, we summarize recent advancements in the understanding of fungal pathogenesis, key features of the host antifungal immune response, and how these findings could be leveraged to design novel approaches to deadly fungal disease.
真菌感染对公共健康构成了日益严重的威胁，而我们现有的抗真菌疗法却难以应对。随着免疫功能低下宿主人群的扩大，以及生态变化有利于真菌病原体的出现，开发新的抗真菌药物，包括疫苗，已成为全球的当务之急。在此，我们总结了近期在真菌感染发病机制、宿主抗真菌免疫反应的关键特征方面的研究进展，以及如何利用这些发现来设计针对致命真菌感染的新方法。
