Pacífico de Carvalho Nathália, Mendicino Cássia Cristina Pinto, Cândido Raissa Carolina Fonseca, Alecrim Denyr Jeferson Dutra, Menezes de Pádua Cristiane Aparecida
a Departamento de Farmácia Social, Faculdade de Farmácia, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.
b Hospital das Clínicas, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil.
AIDS Care. 2019 Oct;31(10):1234-1240. doi: 10.1080/09540121.2019.1612014. Epub 2019 May 1.
Transgender (trans) women are disproportionally burdened by the HIV epidemic due to complex structural, psychosocial and biological factors. HIV pre-exposure prophylaxis (PrEP) is a biomedical prevention approach for people at substantial risk of acquiring HIV. This literature review assessed awareness, willingness to use, and barriers and facilitators for PrEP acceptability among trans women. A search was conducted through five databases and included studies with primary data and disaggregate results for trans women. Of 255 retrieved citations, 17 met the inclusion criteria and were included. Low to moderate knowledge about PrEP was observed among studies. However, willingness to use PrEP was predominantly high. Frequent barriers to PrEP acceptability included concerns about side effects, cost, hormone therapy, adherence, PrEP-related stigma and interaction with healthcare workers. Facilitators included perceived reduction of HIV risk, fear of HIV/AIDS and reduced dependence on partners. Findings suggest elevated interest in PrEP and highlight important barriers and facilitators that should be specifically addressed to optimize PrEP uptake and use among this highly vulnerable population.
由于复杂的结构、心理社会和生物学因素，跨性别女性在艾滋病毒流行中负担过重。艾滋病毒暴露前预防（PrEP）是一种针对有很大感染艾滋病毒风险人群的生物医学预防方法。这篇文献综述评估了跨性别女性对PrEP的知晓率、使用意愿以及PrEP可接受性的障碍和促进因素。通过五个数据库进行了检索，纳入了有原始数据且对跨性别女性进行分类结果分析的研究。在检索到的255篇文献中，17篇符合纳入标准并被纳入。研究中观察到对PrEP的了解程度为低到中等。然而，使用PrEP的意愿大多较高。PrEP可接受性的常见障碍包括对副作用、成本、激素治疗、依从性、与PrEP相关的耻辱感以及与医护人员互动的担忧。促进因素包括认为降低了感染艾滋病毒的风险、对艾滋病毒/艾滋病的恐惧以及减少对伴侣的依赖。研究结果表明对PrEP的兴趣有所提高，并突出了重要的障碍和促进因素，应专门加以解决，以优化这一高度脆弱人群对PrEP的接受和使用。
