Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark.
Alcohol Alcohol. 2019 Jul 1;54(4):446-454. doi: 10.1093/alcalc/agz038.
Alcohol consumption is a modifiable and plausible risk factor for age-related cognitive decline but more longitudinal studies investigating the association are needed. Our aims were to estimate associations of adult-life alcohol consumption and consumption patterns with age-related cognitive decline.
We investigated the associations of self-reported adult-life weekly alcohol consumption and weekly extreme binge drinking (≥10 units on the same occasion) with changes in test scores on an identical validated test of intelligence completed in early adulthood and late midlife in 2498 Danish men from the Lifestyle and Cognition Follow-up study 2015. Analyses were adjusted for year of birth, retest interval, baseline IQ, education and smoking.
Men with adult-life alcohol consumption of more than 28 units/week had a larger decline in IQ scores from early adulthood to late midlife than men consuming 1-14 units/week (B29-35units/week = -3.6; P < 0.001). Likewise, a 1-year increase in weekly extreme binge drinking was associated with a 0.12-point decline in IQ scores (P < 0.001). Weekly extreme binge drinking explained more variance in IQ changes than average weekly consumption. In analyses including mutual adjustment of weekly extreme binge drinking and average weekly alcohol consumption, the estimated IQ decline associated with extreme binge drinking was largely unaffected, whereas the association with weekly alcohol consumption became non-significant.
Adult-life heavy alcohol consumption and extreme binge drinking appear to be associated with larger cognitive decline in men. Moreover, extreme binge drinking may be more important than weekly alcohol consumption in relation to cognitive decline.
饮酒是与年龄相关的认知能力下降相关的可改变和合理的风险因素，但需要更多的纵向研究来调查这种关联。我们的目的是评估成年期饮酒和饮酒模式与与年龄相关的认知能力下降的关系。
我们研究了自我报告的成年期每周饮酒量和每周极端 binge drinking（同一时间内饮用≥10 单位的酒精）与在 Lifestyle and Cognition Follow-up study 2015 中 2498 名丹麦男性在早期成年期和中年后期完成的相同验证性智力测试分数变化之间的关联。分析调整了出生年份、重测间隔、基线智商、教育和吸烟状况。
每周饮酒量超过 28 单位的男性，其智商分数从早期成年期到中年后期的下降幅度大于每周饮酒量为 1-14 单位的男性（29-35 单位/周= -3.6；P < 0.001）。同样，每周极端 binge drinking 增加 1 年与智商分数下降 0.12 分相关（P < 0.001）。每周极端 binge drinking 对智商变化的解释方差大于平均每周饮酒量。在包括每周极端 binge drinking 和平均每周饮酒量相互调整的分析中，与极端 binge drinking 相关的智商下降估计基本不受影响，而与每周饮酒量相关的关联则变得不显著。
成年期大量饮酒和极端 binge drinking 似乎与男性认知能力下降幅度更大有关。此外，与认知能力下降相关，极端 binge drinking 可能比每周饮酒量更为重要。
