电脊髓刺激与神经调节药物的疗效：系统评价。
Efficacy of Electrical Spinal Cord Stimulation with Neuromodulating Medications: A Systematic Review.
机构信息
Nadherny, MD, MetroHealth Rehabilitation Institute of Ohio, Department of PM&R, Cleveland, OH, USA. Fiala, BS, Abd-Elsayed, MD, MPH, FASA, University of Wisconsin School of Medicine and Public Health, Department of Anesthesiology, Madison, WI. Urits, MD, Department of Anesthesiology, Louisiana State University School of Medicine, Shreveport, LA; Beth Israel Deaconess Medical Center, Department of Anesthesiology, Critical Care and Pain Medicine, Harvard Medical School, Boston, MA. Viswanath, MD, Department of Anesthesiology, Louisiana State University School of Medicine, Shreveport, LA; Valley Pain Consultants - Envision Physician Services, Phoenix, AZ; University of Arizona College of Medicine-Phoenix, Department of Anesthesiology, Phoenix, AZ; Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE.
出版信息
Psychopharmacol Bull. 2020 Oct 15;50(4 Suppl 1):67-73.
BACKGROUND
Chronic pain is a prevalent and debilitating problem for millions of people and spinal cord stimulation (SCS) is one option for treatment. It has been shown to have membrane stabilizing properties and is often used in conjunction with medications that are also believed to offer pain control through membrane stabilization.
OBJECTIVE
The goal of this review is to analyze the effects of SCS combined with medications to evaluate for augmentative therapeutic effect.
SETTING
Systematic review.
METHODS
A systematic computerized search of the literature was conducted using PubMed, the Cochrane Library, and EMBASE for articles published in English.
RESULTS
We report three articles that discuss the potential for augmentative effects of medication in combination with SCS. Located articles related primarily to SCS combined with Gabapentin, TCA, or SNRI.
LIMITATIONS
The limited number of articles reflects a need for more investigation in this area.
CONCLUSION
Based on the suspected mechanisms for SCS and neuromodulating medications, there is reason to believe adding these medical therapies may enhance the effects of SCS.
背景
慢性疼痛是数百万人普遍存在且使人虚弱的问题，脊髓刺激（SCS）是一种治疗选择。它已被证明具有稳定细胞膜的特性，并且经常与被认为通过稳定细胞膜来提供疼痛控制的药物一起使用。
目的
本综述的目的是分析 SCS 与药物联合使用的效果，以评估增强治疗效果。
设置
系统评价。
方法
使用 PubMed、Cochrane 图书馆和 EMBASE 对发表在英语中的文献进行了系统的计算机检索。
结果
我们报告了三篇讨论药物与 SCS 联合使用的潜在增效作用的文章。所涉及的文章主要与 SCS 联合加巴喷丁、三环抗抑郁药或 SNRI 有关。
局限性
文章数量有限反映了在这一领域需要更多的研究。
结论
基于 SCS 和神经调节药物的可疑机制，有理由相信添加这些医学治疗方法可能会增强 SCS 的效果。
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