Department of Urology, The Second Hospital of Shandong University, Jinan 250011, China.
Department of Urology, Shandong Provincial Hospital, Shandong 250021, China.
Asian J Androl. 2019 Nov-Dec;21(6):587-591. doi: 10.4103/aja.aja_22_19.
Although elevated prolactin levels have been shown to inhibit penile erection, the relationship between prolactin and erection of the penile tip or base has not been extensively researched. We therefore investigated the prolactin's effects on erection of the penile tip and base, with a cross-sectional study of 135 patients with erectile dysfunction, based on scores of ≤21 on the International Index of Erectile Function-5. All patients were tested for nocturnal penile tumescence, blood pressure, serum glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, luteinizing hormone, follicle-stimulating hormone, prolactin, estradiol, testosterone, and progesterone. Univariate and multivariate analyses were used to assess the associations between prolactin levels and erection at the penile tip and base. We found no obvious relationship between erection time at penile tip and prolactin levels, but observed a negative correlation between base erection time and prolactin level (hazard ratio: -2.68; 95% confidence interval [CI]: -5.13--0.22). With increasing prolactin concentration, multivariate analysis showed obvious reduction in base erection time among patients with normal Rigiscan results (hazard ratio: -3.10; 95% CI: -7.96-1.77; P < 0.05). Our data indicate that prolactin inhibits penile erection, particularly at the penile base. In addition, when the effective erection time of the penile base lasts longer than 10 min, prolactin has a more obvious inhibitory effect on penile base erection.
虽然已证实催乳素水平升高可抑制阴茎勃起，但催乳素与阴茎尖端或根部勃起之间的关系尚未得到广泛研究。因此，我们通过对 135 名勃起功能障碍患者的横断面研究，调查了催乳素对阴茎尖端和根部勃起的影响，这些患者的国际勃起功能指数-5 评分为≤21。所有患者均接受了夜间阴茎勃起测试、血压、血清葡萄糖、总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、黄体生成素、卵泡刺激素、催乳素、雌二醇、睾酮和孕酮检测。采用单变量和多变量分析来评估催乳素水平与阴茎尖端和根部勃起之间的关联。我们发现催乳素水平与阴茎尖端勃起时间之间无明显关系，但观察到催乳素水平与阴茎根部勃起时间呈负相关（危险比：-2.68；95%置信区间 [CI]：-5.13--0.22）。随着催乳素浓度的增加，多变量分析显示在 Rigiscan 结果正常的患者中，阴茎根部勃起时间明显减少（危险比：-3.10；95%CI：-7.96-1.77；P<0.05）。我们的数据表明，催乳素抑制阴茎勃起，尤其是阴茎根部勃起。此外，当阴茎根部有效勃起时间持续超过 10 分钟时，催乳素对阴茎根部勃起的抑制作用更为明显。
