Zafar Mohammad Ishraq, Chen Xiao
Department of Obstetrics and Gynecology, Center for Reproductive Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, N1 Shangcheng Avenue, Yiwu, Zhejiang, China.
Curr Obes Rep. 2024 Jun;13(2):256-274. doi: 10.1007/s13679-024-00557-0. Epub 2024 Mar 15.
Highlight the importance of exploring nutritional interventions that could be applied as alternative or supplementary therapeutic strategies to enhance men's fertility.
Lifestyle choices have prompted extensive discussions regarding its implications and applications as a complementary therapy. The growing concern over the decline in sperm quality underscores the urgency of investigating these alternative interventions. Calorie restriction (CR) has emerged as a promising strategy to improve male fertility. The efficacy of CR depends on factors like age, ethnicity and genetics. Clinical studies, such as CALERIE, have shown an improvement in serum testosterone level and sexual drive in men with or without obesity. Additionally, CR has been shown to positively impact sperm count and motility; however, its effects on sperm morphology and DNA fragmentation remain less clear, and the literature has shown discrepancies, mainly due to the nature of technically dependent assessment tools. The review advocates a personalized approach to CR, considering individual health profiles to maximize its benefits. It underscores the need for routine, accessible diagnostic techniques in male reproductive health. It suggests that future research should focus on personalized dietary interventions to improve male fertility and overall well-being in individuals with or without obesity and unravel CR's immediate and lasting effects on semen parameters in men without obesity.
强调探索可作为替代或补充治疗策略以提高男性生育能力的营养干预措施的重要性。
生活方式的选择引发了关于其作为辅助疗法的意义和应用的广泛讨论。对精子质量下降的日益关注凸显了研究这些替代干预措施的紧迫性。热量限制（CR）已成为改善男性生育能力的一种有前景的策略。CR的效果取决于年龄、种族和基因等因素。诸如热量限制长期效应综合评估（CALERIE）等临床研究表明，无论是否肥胖，男性的血清睾酮水平和性欲都有所改善。此外，CR已被证明对精子数量和活力有积极影响；然而，其对精子形态和DNA碎片的影响仍不太明确，且文献中存在差异，主要是由于技术依赖评估工具的性质所致。该综述主张采用个性化的CR方法，考虑个体健康状况以最大化其益处。它强调了男性生殖健康中常规、可及诊断技术的必要性。它建议未来的研究应聚焦于个性化饮食干预，以改善有或无肥胖个体的男性生育能力和整体健康状况，并揭示CR对非肥胖男性精液参数的即时和持久影响。
