Shi Weisong, Chen Chaoliang, Pasarikovski Christopher R, Gao Wanrong, Yang Victor X D
Appl Opt. 2019 May 1;58(13):3401-3409. doi: 10.1364/AO.58.003401.
We present a differential phase standard-deviation (DPSD)-based optical coherence tomographic (OCT) angiography (OCTA) technique to calculate the angiography images of the human retina. The standard deviation was calculated along the depth direction on the differential phase image of two B-scans (from the same position, at different times) to contrast dynamic vascular signals. The performance of a DPSD was verified by both phantom and in vivo experiments. When compared to other OCTA algorithms such as phase variance OCT, speckle variance OCT, and optical microangiography, we showed that a DPSD achieved improved image contrast and higher sensitivity. Furthermore, we also found the improved signal-to-noise ratio and contrast-to-noise ratio of 1.6 dB and 0.5, respectively, in large scanning range images.
我们提出了一种基于差分相位标准差（DPSD）的光学相干断层扫描（OCT）血管造影（OCTA）技术，用于计算人视网膜的血管造影图像。沿着两个B扫描（来自同一位置、不同时间）的差分相位图像的深度方向计算标准差，以对比动态血管信号。通过模型实验和体内实验验证了DPSD的性能。与其他OCTA算法（如相位方差OCT、散斑方差OCT和光学微血管造影）相比，我们发现DPSD实现了更好的图像对比度和更高的灵敏度。此外，我们还发现在大扫描范围图像中，信噪比和对比噪声比分别提高了1.6 dB和0.5。
