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基于多重缺陷模式的高灵敏度准周期光子晶体生物传感器

High-sensitivity quasi-periodic photonic crystal biosensor based on multiple defective modes.

作者信息

Wang Xiaoqing, Zhou Lin, Zhao Tingting, Liu Xing, Feng Shuai, Chen Xiao, Guo Honglian, Li Chuanbo, Wang Yiquan

出版信息

Appl Opt. 2019 Apr 10;58(11):2860-2866. doi: 10.1364/AO.58.002860.

Abstract

The sensitivities of the octagonal quasi-periodic photonic crystal (QPC) defective modes are theoretically studied. The octagonal QPC biosensors are composed of silicon columns arranged in a liquid background. By designing a defect structure, a variety of localized modes with different spatial symmetries and field profiles are obtained, and a maximum refractive index sensitivity 800 nm/RIU is achieved around 1500 nm transmission peak when the central rod's size equals 100 nm, and the corresponding detection limit reaches 0.00042. The liquid can flow freely among the rods through the entire structure, so it is convenient to monitor the concentration of protein in the liquid environment dynamically. The influence of the protein's thickness to the shift of the resonant wavelength is also studied, where a minimum protein's thickness of less than 10 nm can be detected by optimizing the central column's size to be 400 nm, and the spatial field profiles of different resonant modes are analyzed to explain the corresponding sensitivities.

摘要

从理论上研究了八边形准周期光子晶体(QPC)缺陷模式的灵敏度。八边形QPC生物传感器由排列在液体背景中的硅柱组成。通过设计缺陷结构,获得了具有不同空间对称性和场分布的各种局域模式,当中心杆尺寸等于100nm时,在1500nm传输峰附近实现了最大折射率灵敏度800nm/RIU,相应的检测限达到0.00042。液体可以在杆之间自由流动通过整个结构,因此便于动态监测液体环境中蛋白质的浓度。还研究了蛋白质厚度对共振波长偏移的影响,通过将中心柱尺寸优化为400nm,可以检测到小于10nm的最小蛋白质厚度,并分析了不同共振模式的空间场分布以解释相应的灵敏度。

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