Makkonen T A, Kiminki A, Makkonen T K, Nordman E
Int J Oral Maxillofac Surg. 1987 Feb;16(1):56-64. doi: 10.1016/s0901-5027(87)80031-0.
The case histories of 224 patients treated with radiation therapy for head and neck malignancies at the Radiotherapy Clinic of the University Central Hospital in Turku during the years 1974-77 are reviewed. Of the 92 patients surviving for 5 years, 90 were available for re-examination. The median radiation dosage was 61 Gy in 6 to 8 weeks in patients with squamous cell carcinoma and other solid tumours and 43 Gy in 5 weeks in patients with lymphoma. The oral status of the patients was examined clinically and radiographically. From these patients, 45 teeth had been extracted before irradiation and 94 after irradiation. In no case had this resulted in osteoradionecrosis of the jaws. It is evident that the repairing of patient's teeth before radiation treatment, coupled with continuous preventive care of caries, will prevent serious complications from arising.
回顾了1974年至1977年期间在图尔库大学中心医院放射治疗诊所接受放射治疗的224例头颈部恶性肿瘤患者的病历。在92例存活5年的患者中,90例可供复查。鳞状细胞癌和其他实体瘤患者在6至8周内的中位放射剂量为61 Gy,淋巴瘤患者在5周内的中位放射剂量为43 Gy。对患者的口腔状况进行了临床和影像学检查。这些患者中,45颗牙齿在放疗前已拔除,94颗在放疗后拔除。无一例导致颌骨放射性骨坏死。显然,放疗前修复患者牙齿并持续进行龋齿预防护理,可防止严重并发症的发生。