Huang Li, Chen Yu, Luo Mei, Tang Yancai, Wei Shaobin
College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine.
Department of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Medicine (Baltimore). 2019 May;98(18):e15444. doi: 10.1097/MD.0000000000015444.
Premature ovarian insufficiency (POI) is a difficult-to-treat gynecological disorder with complex etiologies. Although acupuncture has gained increased popularity for the management of POI, evidence regarding its efficacy is lacking. This systematic review protocol aims to describe a meta-analysis to assess the effectiveness and safety of acupuncture for patients with POI.
The following 10 databases will be searched from the publishment to July 2019: PubMed, Embase, the Web of Science, the Cochrane Central Register of Controlled Trials, 4 Chinese databases (China National Knowledge Infrastructure, Wanfang Digital Periodicals, Chinese Biomedical Literature Database, Chinese Scientific Journal Database database), 1 Korean medical database (KoreaMed), 1 Japanese medical database (National Institute of Informatics). The primary outcomes will be the resumption of menstruation and the serum FSH levels, and the secondary outcomes include the serum Estradiol levels, anti-Mullerian hormone levels, antral follicle count, follicular growth, endometrial thickness, and adverse events. We will use RevMan V.5.3 to conduct the meta-analysis, if possible. If it is not allowed, a descriptive analysis or a subgroup analysis will be conducted. Risk ratio for dichotomous data and mean differences or standardized mean differences for continuous data will be calculated with 95% confidence intervals using a random effects model or a fixed effects model.
This study will provide the latest analysis of the currently available evidence for the efficacy of acupuncture in treating POI.
CRD42019125996.
卵巢早衰（POI）是一种病因复杂、难以治疗的妇科疾病。尽管针灸在POI的治疗中越来越受欢迎，但关于其疗效的证据仍然不足。本系统评价方案旨在描述一项荟萃分析，以评估针灸治疗POI患者的有效性和安全性。
检索截至2019年7月发表的以下10个数据库：PubMed、Embase、科学引文索引、Cochrane对照试验中心注册库、4个中文数据库（中国知网、万方数据期刊、中国生物医学文献数据库、维普中文科技期刊数据库）、1个韩国医学数据库（KoreaMed）、1个日本医学数据库（国立情报学研究所）。主要结局指标为月经恢复和血清卵泡刺激素（FSH）水平，次要结局指标包括血清雌二醇水平、抗苗勒管激素水平、窦卵泡计数、卵泡生长、子宫内膜厚度及不良事件。如有可能，我们将使用RevMan V.5.3进行荟萃分析。如果不允许，则进行描述性分析或亚组分析。使用随机效应模型或固定效应模型计算二分类数据的风险比以及连续数据的均值差或标准化均值差，并给出95%置信区间。
本研究将对目前可用的针灸治疗POI疗效证据进行最新分析。
PROSPERO注册号：CRD42019125996。
