Lagergren Katarina, Hammar Mats, Nedstrand Elizabeth, Bladh Marie, Sydsjö Gunilla
Division of Obstetrics and Gynecology, Department of Clinical and Experimental Medicine, Faculty of Medicine and Health Sciences, Linköping University, SE-58185, Linköping, Sweden.
BMC Womens Health. 2018 Oct 25;18(1):175. doi: 10.1186/s12905-018-0665-2.
The current estimates of the prevalence of primary ovarian insufficiency (POI) are very variable, but are in most studies believed to be around 1%. It is also very likely tat the prevalence of POI differs between countries and over time. We therefore aimed to assess the prevalence of primary ovarian insufficiency in Sweden.
All 1,036,918 women born between 1973 and 1993 in Sweden were included. The prevalence of POI was based on data from the Swedish Patient Register through the diagnosis code or through the Prescribed Drug Register. The number of women below 40 years of age diagnosed with the ICD-10 diagnoses E28.3 or E89.4, and women who had been dispensed drugs for treatment of climacteric symptoms were included.
Out of the 1,036,918 women, 19,253 (1.9%) had POI. The prevalence of spontaneous POI was 1.7% and the prevalence of iatrogenic POI was 0.2%. Most women (98.8%) with POI were identified from the Prescribed Drug Register; only 4.1% were found in the Patient Register, whereas 2.9% were identified in both registers.
The total prevalence of POI was 1.9%, 95% CI: 1.7-2.1, indicating a higher prevalence than often previously reported.
目前对原发性卵巢功能不全（POI）患病率的估计差异很大，但在大多数研究中认为约为1%。POI的患病率在不同国家和不同时期也很可能有所不同。因此，我们旨在评估瑞典原发性卵巢功能不全的患病率。
纳入了所有1973年至1993年在瑞典出生的1,036,918名女性。POI的患病率基于瑞典患者登记册通过诊断代码或处方药物登记册的数据。纳入了年龄在40岁以下被诊断为ICD-10编码E28.3或E89.4的女性，以及已配药用于治疗更年期症状的女性。
在1,036,918名女性中，19,253名（1.9%）患有POI。自发性POI的患病率为1.7%，医源性POI的患病率为0.2%。大多数患有POI的女性（98.8%）是从处方药物登记册中识别出来的；只有4.1%是在患者登记册中发现的，而2.9%在两个登记册中都被识别出来。
POI的总患病率为1.9%，95%置信区间：1.7 - 2.1，表明患病率高于先前经常报道的水平。
