From the Departments of Dermatology and Allergy Centre and.
Dermatitis. 2019 May/Jun;30(3):222-226. doi: 10.1097/DER.0000000000000477.
Since the 1990s, gold has been recognized as an important contact allergen.
Based on our results with gold sodium thiosulfate (GST) in the TRUE Test patch test system in the baseline series, the aims of the study were to evaluate baseline testing with gold salts worldwide and to discuss relevance.
Patients with positive patch test reactions to GST were questioned on exposure at day 7 reading.
In a 1-year period, 89 (18.5%) of 480 patients tested positive to GST, making this the most frequent contact allergy. The 89 patients comprised 18 males and 71 females. The reaction was considered relevant in 21%; this is a minimum figure because 2 patients were withdrawn because of unknown relevance and because clinical features suggestive of gold contact allergy at distant sites, such as the face, were not taken into account. Altogether, 88% had been exposed. Worldwide, the prevalence of gold sensitization ranges between 0.78% and 30.7%, and relevance, in larger studies, has been between 15% and 20% of patients. The use of earrings and the presence of dental gold were important sources of exposure.
Because it may be difficult to diagnose gold allergy, screening may be recommended when history taken suggests gold exposure.
自 20 世纪 90 年代以来，金已被确认为一种重要的接触过敏原。
基于我们在 TRUE Test 斑贴试验系统中使用金钠硫代硫酸盐（GST）的结果，本研究旨在评估全球范围内的金盐基线检测，并讨论其相关性。
对 GST 斑贴试验阳性的患者在第 7 天读取时进行暴露情况询问。
在 1 年期间，480 名接受测试的患者中有 89 名（18.5%）对 GST 呈阳性反应，这是最常见的接触过敏。89 名患者包括 18 名男性和 71 名女性。21%的患者认为该反应具有相关性；这是一个最低数字，因为有 2 名患者因相关性未知而被排除，并且因为面部等远离过敏部位的金接触过敏的临床特征未被考虑在内。总的来说，88%的患者有过暴露。全球范围内，金敏化的患病率在 0.78%至 30.7%之间，而在更大规模的研究中，相关性在 15%至 20%的患者中。耳环的使用和牙科金的存在是重要的暴露源。
由于金过敏的诊断可能较为困难，因此当病史提示有金暴露时，可能需要进行筛查。
