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日本曲安西龙/新霉素贴片试验(TRUE Test)中对金钠硫代硫酸钠的阳性反应:一项多中心研究。

Positive reactions to gold sodium thiosulfate in patch test panels (TRUE Test) in Japan: A multicentre study.

机构信息

Department of Allergology, Fujita Health University Second Educational Hospital, Aichi, Japan.

Department of Dermatology, Nagata Clinic, Niigata, Japan.

出版信息

Contact Dermatitis. 2019 Feb;80(2):114-117. doi: 10.1111/cod.13105. Epub 2018 Sep 10.

DOI:10.1111/cod.13105
PMID:30198192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6585663/
Abstract

BACKGROUND

The proportion of positive test results with gold sodium thiosulfate included in a patch test panel (P-GST) had been found to be greater than that with gold sodium thiosulfate 0.5% pet. by allergEAZE (A-GST).

OBJECTIVES

To compare positive reactions to P-GST and A-GST, and to evaluate late reactions after the day (D) 7 reading.

METHODS

A retrospective analysis was performed of 588 patients at participating departments (119 males; 469 females) who were patch tested with P-GST and A-GST in May 2015 to March 2016.

RESULTS

Positive test reactions to P-GST and A-GST were observed in 15% and 6% of patients, respectively. Three patients reported a positive reaction occurring after the D7 reading.

CONCLUSIONS

Gold sodium thiosulfate often gives a positive reaction after 2 to 3 weeks, and, in such cases, the positive reaction may be sustained, so it is recommended to assess the reaction for up to 1 month after application.

摘要

背景

与 AllergEAZE(A-GST)相比,包含在斑贴试验组合中的金硫代硫酸钠(P-GST)的阳性测试结果比例更高。

目的

比较 P-GST 和 A-GST 的阳性反应,并评估 D7 读取后的迟发反应。

方法

对 2015 年 5 月至 2016 年 3 月参加研究的 588 名患者(男 119 名,女 469 名)进行了回顾性分析,这些患者均使用 P-GST 和 A-GST 进行了斑贴试验。

结果

分别有 15%和 6%的患者对 P-GST 和 A-GST 出现阳性测试反应。3 名患者报告说,D7 读取后出现阳性反应。

结论

金硫代硫酸钠通常在 2 至 3 周后出现阳性反应,在这种情况下,阳性反应可能持续存在,因此建议在应用后评估 1 个月。

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本文引用的文献

1
Gold contact allergy: clues and controversies.金接触性过敏:线索与争议
Dermatitis. 2015 Mar-Apr;26(2):69-77. doi: 10.1097/DER.0000000000000101.
2
The development and course of test reactions to gold sodium thiosulfate.硫代硫酸钠金钠试验反应的发展与过程。
Contact Dermatitis. 1995 Dec;33(6):386-91. doi: 10.1111/j.1600-0536.1995.tb02072.x.
3
A case of contact hypersensitivity to metallic gold.一例对金属金的接触性过敏病例。
Arch Dermatol. 1969 Jun;99(6):720-3.
4
The thin layer rapid use epicutaneous test (TRUE-test), a new patch test method with high accuracy.薄层快速使用表皮试验(TRUE试验),一种具有高准确性的新型斑贴试验方法。
Br J Dermatol. 1985 Jan;112(1):63-8. doi: 10.1111/j.1365-2133.1985.tb02292.x.
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Selection of patch test materials for gold allergy.金过敏斑贴试验材料的选择。
Contact Dermatitis. 1987 Jul;17(1):23-5. doi: 10.1111/j.1600-0536.1987.tb02639.x.