Möller H, Larsson A, Björkner B, Bruze M
Department of Dermatology, Lund University, Malmö, Sweden.
Acta Derm Venereol. 1994 Nov;74(6):417-23. doi: 10.2340/0001555574417423.
Gold sodium thiosulfate, inserted in the patch test standard series, gives a surprisingly high yield of positive reactions, about 10% of tested eczema patients, but with a low degree of clinical relevance. A histopathological study on patch test reactions was carried out in patients selected because of a combined contact allergy to gold sodium thiosulfate and nickel. Biopsies were taken from macroscopically similar reactions in dilution series of each allergen. The histological picture was clearly eczematous, without irritative features. In a blind comparison, test reactions induced by the two allergens could not be differentiated from each other. Long-lasting patch test reactions to gold sodium thiosulfate were characterized by an intense lymphocytic dermal infiltrate without epidermal involvement. Immunohistochemically, CD4+ and CD8+ T lymphocytes could be detected already 4-8 h post-challenge, and "naive" as well as "memory"-type T cells were demonstrated. Apparently, our findings reflect a true contact allergy to gold sodium thiosulfate.
硫代硫酸钠金钠被列入斑贴试验标准系列，其阳性反应发生率出奇地高，约10%的受试湿疹患者会出现阳性反应，但临床相关性较低。对因对硫代硫酸钠金钠和镍产生联合接触性过敏而入选的患者进行了斑贴试验反应的组织病理学研究。从每种变应原稀释系列中宏观相似的反应处取活检组织。组织学表现明显为湿疹样，无刺激性特征。在一项盲法比较中，无法区分由这两种变应原引起的试验反应。对硫代硫酸钠金钠的持久斑贴试验反应的特征是真皮有强烈的淋巴细胞浸润，不累及表皮。免疫组织化学显示，激发后4 - 8小时即可检测到CD4 +和CD8 + T淋巴细胞，同时还证实了“初始”型和“记忆”型T细胞的存在。显然，我们的研究结果反映了对硫代硫酸钠金钠的真正接触性过敏。
