Comparison of Monoclonal Antibodies for Treatment of Uncontrolled Eosinophilic Asthma.

OBJECTIVE

To summarize the current literature for Food and Drug Administration (FDA)-approved monoclonal antibodies used as add-on maintenance therapy in uncontrolled eosinophilic asthma.

DATA SOURCES

PubMed was searched on December 17, 2018 using keywords: .

STUDY SELECTION

Studies evaluating safety and efficacy of monoclonal antibodies for treatment of severe or eosinophilic asthma were included.

RESULTS

Twenty-one randomized, double-blind, placebo-controlled trials evaluating the current FDA-approved monoclonal antibodies (omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab) for the treatment of uncontrolled eosinophilic asthma were included. The studies demonstrated clinically significant reductions in asthma exacerbations, symptoms, emergency room visits, eosinophil counts, and improvements in pulmonary function and asthma-related quality of life.

CONCLUSION

Five monoclonal antibodies are available for uncontrolled eosinophilic asthma. Choice depends on patient factors. Future studies should focus on cost-effectiveness of treatment, drug-drug comparisons, and long-term efficacy and safety.