Sokomba E, Wambebe C, Chowdhury B K, Iriah J, Ogbeide O N, Orkor D
J Ethnopharmacol. 1986 Nov;18(2):173-85. doi: 10.1016/0378-8741(86)90029-2.
Preliminary phytochemical investigation of the leaves of Synclisia scabrida indicated the presence of two alkaloids in the water extracts and five alkaloids in the ethanol extracts. The alkaloidal fraction obtained from the cold ethanol extract furnished on column-chromatography, a homogeneous amorphous solid which has been designated as alkaloid C. Alkaloid C showed positive test for alkaloids. The UV and IR spectra and colour reactions of alkaloid C indicated that the compound may be a phenolic bisbenzylisoquinoline alkaloid. All the extracts delayed the onset and shortened the duration of apomorphine-induced stereotyped behaviour in chicks. In addition, 40 mg kg-1 i.p. of the ethanolic extract induced catalepsy in rats. The cold water extract (CWE) synchronized the EEG of the hyperstriatum, optic tectum and the reticular formation while the EMG activity was slightly enhanced. The hot ethanol alkaloidal extract (HEE) inhibited the growth of Pseudomonas aeruginosa and Staphylococcus aureus. The minimum inhibitory concentration of HEE on Pseudomonas aeruginosa strains I and II were 5 and 2.5 micrograms/ml while for Staphylococcus aureus strains I and II were 5 and 10 micrograms/ml, respectively. Up to 1 g kg-1 i.p. of the extract failed to induce any lethal effect in chicks and rats. These effects of the leaf extracts of Synclisia scabrida Miers support some of the local uses of the plant by traditional medical practitioners.
对糙叶合耳菊叶片进行的初步植物化学研究表明，其水提取物中存在两种生物碱，乙醇提取物中存在五种生物碱。从冷乙醇提取物中获得的生物碱部分经柱色谱法得到一种均一的无定形固体，被命名为生物碱C。生物碱C对生物碱呈阳性反应。生物碱C的紫外光谱、红外光谱和颜色反应表明该化合物可能是一种酚性双苄基异喹啉生物碱。所有提取物均延迟了阿扑吗啡诱导的雏鸡刻板行为的发作并缩短了其持续时间。此外，腹腔注射40 mg/kg的乙醇提取物可使大鼠产生僵住症。冷水提取物（CWE）使上纹状体、视顶盖和网状结构的脑电图同步，同时肌电图活动略有增强。热乙醇生物碱提取物（HEE）抑制铜绿假单胞菌和金黄色葡萄球菌的生长。HEE对铜绿假单胞菌菌株I和II的最低抑菌浓度分别为5和2.5微克/毫升，而对金黄色葡萄球菌菌株I和II的最低抑菌浓度分别为5和10微克/毫升。腹腔注射高达1 g/kg的提取物未在雏鸡和大鼠中诱导任何致死效应。糙叶合耳菊叶片提取物的这些作用支持了传统医学从业者对该植物的一些局部应用。
