Department of Medicine, APC Microbiome Ireland, University College Cork, Cork, Ireland.
School of Microbiology, APC Microbiome Ireland, University College Cork, Cork, Ireland.
Gastroenterol Clin North Am. 2019 Jun;48(2):221-235. doi: 10.1016/j.gtc.2019.02.003. Epub 2019 Apr 5.
The gut microbiome is fundamental to human health and development. Altered microbiomes have been associated with many diseases. However, variation between individuals, environmental effects, and a lack of standardization across studies makes differentiation between health and disease challenging. Large-scale population cohorts in different countries will be required to match disease subjects with healthy controls, whereas standardized, reproducible pipelines for analysis are required to compare findings between studies. Despite this, several conditions have already demonstrated great promise for developing microbiome-based biomarkers as well as providing a gateway into integrated personalized medicine.
肠道微生物组对人类健康和发育至关重要。微生物组的改变与许多疾病有关。然而，个体之间的差异、环境影响以及研究之间缺乏标准化，使得区分健康和疾病具有挑战性。需要在不同国家的大型人群队列中匹配疾病受试者与健康对照，同时需要标准化、可重复的分析管道来比较研究结果。尽管如此，一些疾病已经显示出很大的潜力，可以开发基于微生物组的生物标志物，并为整合个性化医学提供途径。
