食管和胃肿瘤的分子生物学基础。
The Molecular Biologic Basis of Esophageal and Gastric Cancers.
机构信息
Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, The University of Pittsburgh School of Medicine, University of Pittsburgh, 200 Lothrop St. Suite C-800, Pittsburgh, PA 15213, USA.
Department of Surgery, Boston University School of Medicine, 700 Albany St, Boston, MA 02118, USA.
出版信息
Surg Clin North Am. 2019 Jun;99(3):403-418. doi: 10.1016/j.suc.2019.02.010.
Esophageal cancer and gastric cancer are leading causes of cancer-related mortality worldwide. In this article, the authors discuss the molecular biology of esophageal and gastric cancer with a focus on esophageal adenocarcinoma. They review data from The Cancer Genome Atlas project and advances in the molecular stratification and classification of esophageal carcinoma and gastric cancer. They also summarize advances in microRNA, molecular staging, gene expression profiling, tumor microenvironment, and detection of circulating tumor DNA. Finally, the authors summarize some of the implications of understanding the molecular basis of esophageal cancer and future directions in the management of esophageal cancer.
食管癌和胃癌是全球癌症相关死亡的主要原因。本文作者讨论了食管癌和胃癌的分子生物学，重点是食管腺癌。他们回顾了癌症基因组图谱项目的数据以及食管癌和胃癌的分子分层和分类的进展。他们还总结了 microRNA、分子分期、基因表达谱、肿瘤微环境和循环肿瘤 DNA 检测方面的进展。最后，作者总结了了解食管癌分子基础的一些意义和食管癌治疗的未来方向。
Zotero 插件