Zhang Lihan, Li Xing, Yue Guangxing, Guo Lihao, Hu Yanhui, Cui Qingli, Wang Jia, Tang Jingwen, Liu Huaimin
Department of Integrated Chinese and Western Medicine, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.
Department of General Surgery, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.
Front Bioeng Biotechnol. 2023 Jul 13;11:1233476. doi: 10.3389/fbioe.2023.1233476. eCollection 2023.
With the increasing incidence of esophageal cancer, its diagnosis and treatment have become one of the key issues in medical research today. However, the current diagnostic and treatment methods face many unresolved issues, such as low accuracy of early diagnosis, painful treatment process for patients, and high recurrence rate after recovery. Therefore, new methods for the diagnosis and treatment of esophageal cancer need to be further explored, and the rapid development of nanomaterials has brought new ideas for solving this problem. Nanomaterials used as drugs or drug delivery systems possess several advantages, such as high drug capacity, adjustably specific targeting capability, and stable structure, which endow nanomaterials great application potential in cancer therapy. However, even though the nanomaterials have been widely used in cancer therapy, there are still few reviews on their application in esophageal cancer, and systematical overview and analysis are deficient. Herein, we overviewed the application of nanodrug systems in therapy and diagnosis of esophageal cancer and summarized some representative case of their application in diagnosis, chemotherapy, targeted drug, radiotherapy, immunity, surgery and new therapeutic method of esophageal cancer. In addition, the nanomaterials used for therapy of esophageal cancer complications, esophageal stenosis or obstruction and oesophagitis, are also listed here. Finally, the challenge and the future of nanomaterials used in cancer therapy were discussed.
随着食管癌发病率的不断上升，其诊断和治疗已成为当今医学研究的关键问题之一。然而，目前的诊断和治疗方法面临许多尚未解决的问题，如早期诊断准确性低、患者治疗过程痛苦以及康复后复发率高。因此，需要进一步探索食管癌的新诊断和治疗方法，而纳米材料的快速发展为解决这一问题带来了新的思路。用作药物或药物递送系统的纳米材料具有几个优点，如高载药量、可调节的特异性靶向能力和稳定的结构，这些赋予了纳米材料在癌症治疗中巨大的应用潜力。然而，尽管纳米材料已广泛应用于癌症治疗，但关于其在食管癌中的应用的综述仍然很少，缺乏系统的概述和分析。在此，我们综述了纳米药物系统在食管癌治疗和诊断中的应用，并总结了其在食管癌诊断、化疗、靶向药物、放疗、免疫、手术及新治疗方法等方面应用的一些代表性案例。此外，还列出了用于治疗食管癌并发症、食管狭窄或梗阻以及食管炎的纳米材料。最后，讨论了纳米材料在癌症治疗中面临的挑战和未来发展方向。
