College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, PR China; Wood Technology and Wood Chemistry, Georg-August-University of Goettingen, Büsgenweg 4, 37077 Göttingen, Germany.
Wood Technology and Wood Chemistry, Georg-August-University of Goettingen, Büsgenweg 4, 37077 Göttingen, Germany.
Carbohydr Polym. 2019 Jul 15;216:113-118. doi: 10.1016/j.carbpol.2019.04.029. Epub 2019 Apr 8.
A controllable drug delivery system demonstrates a promising tool for diverse biomedical applications. In this work, a group of amphiphilic macromolecules was designed and prepared via Schiff base reactions between 2,3-dialdehyde cellulose (DAC) with oleylamine and amino-containing compounds. Benefiting from the self-assemble process of these amphiphilic macromolecules in the poor solvent, a group of novel pH-responsive nanoparticles (NPs) were facilely fabricated by using nanoprecipitation dropping technique. The high amount of aldehyde groups on DAC chains enabled immobilization of tunable amounts of amine compounds (up to 1.67 mmol/g) in the NPs. Furthermore, the Schiff base bonds in NPs allowed the efficient release of the drug in acidic tumor microenvironment by cleaving the Schiff base linkages. This study demonstrates the formation of a group of novel pH-sensitive and drug-loadable NPs, which provide a simple and efficient drug delivery system for the potential application for cancer treatment.
一种可控药物输送系统展示了一种用于各种生物医学应用的有前途的工具。在这项工作中，通过 2,3-二醛纤维素（DAC）与油胺和含氨基化合物之间的席夫碱反应设计并制备了一组两亲性大分子。得益于这些两亲性大分子在不良溶剂中的自组装过程，通过纳米沉淀滴注技术简便地制备了一组新型 pH 响应性纳米颗粒（NPs）。DAC 链上高含量的醛基使 NPs 中可固定的胺化合物的量（高达 1.67mmol/g）可调。此外，NPs 中的席夫碱键通过切断席夫碱键能够在酸性肿瘤微环境中有效释放药物。本研究证明了一组新型 pH 敏感和载药纳米颗粒的形成，为癌症治疗的潜在应用提供了一种简单高效的药物输送系统。
