Brooks B R, Sufit R L, Montgomery G K, Beaulieu D A, Erickson L M
Neurol Clin. 1987 Feb;5(1):143-58.
Focal, small-to-moderate and transient improvement occurred in the muscle strength and function of patients with ALS who received TRH in dose-response and screening studies. In a small pilot study of 12 patients, 3 months administration of TRH at 10 mg per kg on alternate days resulted in localized increased strength of jaw muscles as well as significant improvement in lower extremity function. Aerobic exercise capacity was particularly improved in patients with ALS following administration of TRH. Autonomic effects of TRH on heart rate, respiration, and blood pressure were not serious and attenuated slightly over the course of the study.
在剂量反应和筛查研究中，接受促甲状腺激素释放激素（TRH）治疗的肌萎缩侧索硬化症（ALS）患者的肌肉力量和功能出现了局灶性、轻度至中度且短暂的改善。在一项针对12名患者的小型试点研究中，每隔一天给予10毫克/千克的TRH，持续给药3个月，导致颌部肌肉局部力量增强，以及下肢功能显著改善。TRH给药后，ALS患者的有氧运动能力尤其得到改善。TRH对心率、呼吸和血压的自主神经效应并不严重，且在研究过程中略有减弱。
