Gueguen B, Puymirat J, Grouselle D, Piketty M L, Bleton J P, Bourdel M C, Rondot P
Service de Neurologie, Hôpital Sainte-Anne, Paris.
Rev Neurol (Paris). 1988;144(11):704-9.
Eight patients with amyotrophic lateral sclerosis received 500 mg TRH by IV infusion, at a progressive rate during 3 hours. Only 3 patients noted subjective improvement of strength. Clinical muscular testing and H response study failed to show any change. Moreover modifications of the prolactin, growth hormone, TSH and T3 serum levels raise a question concerning the tolerance with long term utilization of TRH.
