Serratrice G, Desnuelle C, Crevat A, Guelton C, Meyer-Dutour A
Rev Neurol (Paris). 1986;142(2):133-9.
Nine patients (7 with amyotrophic lateral sclerosis, 1 with progressive spinal amyotrophy and 1 with chronic anterior poliomyelitis) were treated by sequential intravenous administration of 240 mg of TRH over one hour every two weeks. Results were assessed by an analytical evaluation of muscle strength before and 24 h after each infusion and by objective and subjective evaluation of spasticity. Significant improvement, as shown by statistical analysis, was noted in muscle strength in the 9 patients by 5 infusions over a 4-week period and a sub-group of 5 patients treated by 8 infusions over 10 weeks. Continued use of this therapy is justified by the need to determine its long-term effects and the psychological improvement noted in some patients after an even transient improvement in motor performance. However this treatment is obviously not curative.
9例患者（7例肌萎缩侧索硬化症、1例进行性脊髓性肌萎缩症和1例慢性脊髓灰质炎）接受了治疗，每两周一次，在1小时内静脉输注240毫克促甲状腺激素释放激素（TRH）。通过每次输注前和输注后24小时对肌肉力量的分析评估以及对痉挛的客观和主观评估来评估结果。统计分析显示，9例患者在4周内输注5次后肌肉力量有显著改善，5例患者亚组在10周内输注8次后肌肉力量也有显著改善。由于需要确定其长期效果以及部分患者在运动表现出现短暂改善后出现的心理改善，因此继续使用这种疗法是合理的。然而，这种治疗显然不能治愈疾病。
