运动神经元病患者临床评估观察。促甲状腺激素释放激素类似物的经验。
Observations on the clinical assessment of patients with motor neuron disease. Experience with a TRH analogue.
作者信息
Guiloff R J, Eckland D J
出版信息
Neurol Clin. 1987 Feb;5(1):171-92.
PMID:3104752
Abstract
The need for improved assessment techniques in order to monitor the action of substances active in upper and lower motor neuron systems in motor neuron disease is discussed. A long-acting TRH analogue is shown to have detectable acute effects on bulbar symptoms, particularly speech, tone, fasciculations, and muscle force. Endocrine surveillance is essential in studies with TRH and analogues.
摘要
讨论了为监测运动神经元疾病中上下运动神经元系统活性物质的作用而改进评估技术的必要性。一种长效促甲状腺激素释放激素类似物对延髓症状，特别是言语、肌张力、肌束震颤和肌力有可检测到的急性影响。在促甲状腺激素释放激素及其类似物的研究中，内分泌监测至关重要。
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