Guiloff R J, Modarres-Sadeghi H, Stålberg E, Rogers H
Department of Neurology, Westminster Hospital, London, UK.
J Neurol Neurosurg Psychiatry. 1988 May;51(5):671-6. doi: 10.1136/jnnp.51.5.671.
Thirty five individual macro EMG motor unit potentials in 13 patients with motor neuron disease were recorded every 15 minutes during a 2 hour period. No significant change in amplitude or area was seen in 15 control units in nine patients or in 20 units in 11 patients receiving RX77368 0.2-0.3 mg/kg. The findings provide no evidence for an action of this long acting TRH analogue on the peripheral territory of motor units in motor neuron disease.
在2小时内，每隔15分钟记录13例运动神经元病患者的35个单个肌电图运动单位电位。9例患者的15个对照单位或11例接受0.2 - 0.3mg/kg RX77368治疗的患者的20个单位中，电位幅度或面积均无显著变化。这些发现没有提供证据表明这种长效促甲状腺激素释放激素类似物对运动神经元病运动单位的外周区域有作用。
