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接受促甲状腺激素释放激素类似物（RX77368）治疗的运动神经元病患者的电生理观察

Electrophysiological observations in patients with motor neuron disease receiving a thyrotropin releasing hormone analogue (RX77368).

作者信息

Guiloff R J, Stålberg E, Eckland D J, Lightman S L

机构信息

Department of Neurology, Westminster Hospital, Charing Cross and Westminster Medical School, London, UK.

出版信息

J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1633-40. doi: 10.1136/jnnp.50.12.1633.

DOI:10.1136/jnnp.50.12.1633
PMID:3125307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1032605/
Abstract

Twenty nine patients with motor neuron disease receiving a thyrotropin releasing hormone analogue showed acute 25-30% increase in mean corrected fibre density and mean macro EMG median amplitude and area in brachial biceps muscle. The data are consistent with a direct or indirect action of the drug on anterior horn cells.

摘要

29例运动神经元病患者接受促甲状腺激素释放激素类似物治疗后，肱二头肌的平均校正纤维密度、平均巨肌电图中位波幅和面积急性增加了25%-30%。这些数据与该药物对前角细胞的直接或间接作用一致。

相似文献

1
Electrophysiological observations in patients with motor neuron disease receiving a thyrotropin releasing hormone analogue (RX77368).接受促甲状腺激素释放激素类似物（RX77368）治疗的运动神经元病患者的电生理观察
J Neurol Neurosurg Psychiatry. 1987 Dec;50(12):1633-40. doi: 10.1136/jnnp.50.12.1633.
2
Short-term stability of single motor unit recordings in motor neuron disease: a macro EMG study.运动神经元病中单运动单位记录的短期稳定性：一项宏肌电图研究。
J Neurol Neurosurg Psychiatry. 1988 May;51(5):671-6. doi: 10.1136/jnnp.51.5.671.
3
Controlled acute trial of a thyrotrophin releasing hormone analogue (RX77368) in motor neuron disease.促甲状腺激素释放激素类似物（RX77368）用于运动神经元病的对照急性试验。
J Neurol Neurosurg Psychiatry. 1987 Oct;50(10):1359-70. doi: 10.1136/jnnp.50.10.1359.
4
The effects of repeated administration of a long acting TRH analogue (RX77368), on TSH, T4, T3 and prolactin in patients with motor neuron disease.长效促甲状腺激素释放激素类似物（RX77368）反复给药对运动神经元病患者促甲状腺激素、甲状腺素、三碘甲状腺原氨酸和催乳素的影响。
J Neurol Neurosurg Psychiatry. 1990 Sep;53(9):803-4. doi: 10.1136/jnnp.53.9.803-a.
5
Observations on the clinical assessment of patients with motor neuron disease. Experience with a TRH analogue.运动神经元病患者临床评估观察。促甲状腺激素释放激素类似物的经验。
Neurol Clin. 1987 Feb;5(1):171-92.
6
Motoneurone excitability after administration of a thyrotrophin releasing hormone analogue.注射促甲状腺激素释放激素类似物后的运动神经元兴奋性
Br J Pharmacol. 1983 Nov;80(3):561-5. doi: 10.1111/j.1476-5381.1983.tb10729.x.
7
Subacute administration of a TRH analogue (RX77368) in motorneuron disease: an open study.促甲状腺激素释放激素类似物（RX77368）在运动神经元病中的亚急性给药：一项开放性研究。
J Neurol Neurosurg Psychiatry. 1988 Sep;51(9):1146-57. doi: 10.1136/jnnp.51.9.1146.
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Comparative efficacy and safety of intravenous and oral administration of a TRH analogue (RX77368) in motor neuron disease.促甲状腺激素释放激素类似物（RX77368）静脉注射与口服给药在运动神经元病中的疗效和安全性比较
J Neurol Neurosurg Psychiatry. 1990 Nov;53(11):944-7. doi: 10.1136/jnnp.53.11.944.
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Potentiation of motoneurone excitability by combined administration of 5-HT agonist and TRH analogue.
Neuropeptides. 1985 Jun;6(3):269-82. doi: 10.1016/0143-4179(85)90098-8.
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Motoneurone excitability during antidromically evoked inhibition after administration of a thyrotrophin releasing hormone (TRH) analogue.
Neuropeptides. 1984 Sep;4(5):403-11. doi: 10.1016/0143-4179(84)90115-x.

引用本文的文献

1
Treatment for cramps in amyotrophic lateral sclerosis/motor neuron disease.肌萎缩侧索硬化症/运动神经元病中痉挛的治疗
Cochrane Database Syst Rev. 2012 Apr 18(4):CD004157. doi: 10.1002/14651858.CD004157.pub2.
2
Short-term stability of single motor unit recordings in motor neuron disease: a macro EMG study.运动神经元病中单运动单位记录的短期稳定性：一项宏肌电图研究。
J Neurol Neurosurg Psychiatry. 1988 May;51(5):671-6. doi: 10.1136/jnnp.51.5.671.
3
Pharmacological and biochemical comparison of thyrotropin releasing hormone (TRH) and di-methyl proline-TRH on pituitary GH3 cells.促甲状腺激素释放激素（TRH）与二甲基脯氨酸-TRH对垂体GH3细胞的药理及生化比较
Br J Pharmacol. 1990 Nov;101(3):615-20. doi: 10.1111/j.1476-5381.1990.tb14129.x.

本文引用的文献

1
Macro EMG, a new recording technique.宏肌电图，一种新的记录技术。
J Neurol Neurosurg Psychiatry. 1980 Jun;43(6):475-82. doi: 10.1136/jnnp.43.6.475.
2
Electrophysiological cross section of the motor unit.运动单位的电生理横断面。
J Neurol Neurosurg Psychiatry. 1980 Jun;43(6):469-74. doi: 10.1136/jnnp.43.6.469.
3
Macro EMG in healthy subjects of different ages.不同年龄健康受试者的巨肌电图
J Neurol Neurosurg Psychiatry. 1982 Oct;45(10):870-8. doi: 10.1136/jnnp.45.10.870.
4
Ventral root depolarization and spinal reflex augmentation by a TRH analog in rat spinal cord.促甲状腺激素释放激素类似物对大鼠脊髓腹根去极化及脊髓反射增强作用
Neuropharmacology. 1982 Aug;21(8):739-44. doi: 10.1016/0028-3908(82)90058-2.
5
Neuropharmacological evaluation of RX 77368--a stabilised analogue of thyrotropin-releasing hormone (TRH).RX 77368的神经药理学评估——促甲状腺激素释放激素（TRH）的一种稳定类似物。
Regul Pept. 1982 Mar;3(3-4):193-206. doi: 10.1016/0167-0115(82)90125-2.
6
Thyrotropin-releasing hormone (TRH) analogues show enhanced CNS selectivity because of increased biological stability.
Regul Pept. 1981 Sep;2(5):277-84. doi: 10.1016/0167-0115(81)90032-x.
7
Biologically stable analogues of TRH with increased neuropharmacological potency.
Neuropharmacology. 1981 May;20(5):497-503. doi: 10.1016/0028-3908(81)90184-2.
8
Motoneurone excitability during antidromically evoked inhibition after administration of a thyrotrophin releasing hormone (TRH) analogue.
Neuropeptides. 1984 Sep;4(5):403-11. doi: 10.1016/0143-4179(84)90115-x.
9
Motoneurone excitability after administration of a thyrotrophin releasing hormone analogue.注射促甲状腺激素释放激素类似物后的运动神经元兴奋性
Br J Pharmacol. 1983 Nov;80(3):561-5. doi: 10.1111/j.1476-5381.1983.tb10729.x.
10
Simulation of macro EMG motor unit potentials.宏肌电图运动单位电位的模拟。
Electroencephalogr Clin Neurophysiol. 1983 Jul;56(1):52-62. doi: 10.1016/0013-4694(83)90006-8.