Montgomery G K, Erickson L M
Neurol Clin. 1987 Feb;5(1):61-81.
Three aspects of neuropsychological functioning in patients with ALS are examined. Contrary to previous research, a new psychometric study of psychological adjustment suggested significant depression-distress in this population and related psychological disturbance differentially to signs of upper versus lower motor neuron involvement and to respiratory failure. An association between ALS and impaired neuropsychological functioning is discussed through an examination of the clinical and pathologic literatures. ALS appears to be a multisystem degenerative disease with a variety of expressions that may frequently include loss of cognitive-behavioral competency with progressive involvement of the prefrontal cortex and, in a few instances, profound dementia. Finally, the article describes an analysis of trends in psychological adjustment and in the perception of physical capability over the course of a pilot clinical trial.
对肌萎缩侧索硬化症（ALS）患者神经心理功能的三个方面进行了研究。与先前的研究相反，一项关于心理调适的新心理测量学研究表明，该人群存在明显的抑郁困扰，且心理障碍与上、下运动神经元受累体征及呼吸衰竭存在差异相关。通过对临床和病理文献的研究，探讨了ALS与神经心理功能受损之间的关联。ALS似乎是一种多系统退行性疾病，有多种表现形式，常包括随着前额叶皮质逐渐受累而出现的认知行为能力丧失，在少数情况下还会出现严重痴呆。最后，本文描述了在一项试点临床试验过程中对心理调适趋势和身体能力认知趋势的分析。
