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白细胞介素2对人T淋巴细胞基因表达的调控：即时反应基因包括原癌基因c-myb。

Regulation of human T-lymphocyte gene expression by interleukin 2: immediate-response genes include the proto-oncogene c-myb.

作者信息

Pauza C D

出版信息

Mol Cell Biol. 1987 Jan;7(1):342-8. doi: 10.1128/mcb.7.1.342-348.1987.

DOI:10.1128/mcb.7.1.342-348.1987
PMID:3104767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC365074/
Abstract

Antigen-stimulated human T lymphocytes must bind the immunoregulatory hormone interleukin 2 (IL-2) if they are to transit from the G1 to the S phase of the cell cycle. Indirect methods, such as the measurement of thymidine uptake rates, were previously the only means available for exploring the mechanism of action of IL-2. Several cDNA clones have been isolated which are expressed subsequent to IL-2 binding, and the expression of two of these genes. Tact52 and Tact75, is regulated directly at the level of transcription; expression of the proto-oncogene c-myb is also regulated directly by IL-2 binding. These genes thus constitute a set which is coordinately regulated in the course of the transition from G1 to S phase of human T lymphocytes, and their expression depends on IL-2 binding.

摘要

抗原刺激的人类T淋巴细胞若要从细胞周期的G1期过渡到S期，就必须结合免疫调节激素白细胞介素2（IL-2）。间接方法，如测量胸腺嘧啶核苷摄取率，以前是探索IL-2作用机制的唯一可用手段。已经分离出几个在IL-2结合后表达的cDNA克隆，其中两个基因Tact52和Tact75的表达在转录水平受到直接调控；原癌基因c-myb的表达也受到IL-2结合的直接调控。因此，这些基因构成了一组在人类T淋巴细胞从G1期过渡到S期的过程中受到协同调控的基因，它们的表达依赖于IL-2结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d335/365074/6e4cb15cce0d/molcellb00073-0365-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d335/365074/e16c4afecd63/molcellb00073-0363-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d335/365074/78d2ee958763/molcellb00073-0364-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d335/365074/6e4cb15cce0d/molcellb00073-0365-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d335/365074/e16c4afecd63/molcellb00073-0363-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d335/365074/78d2ee958763/molcellb00073-0364-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d335/365074/6e4cb15cce0d/molcellb00073-0365-a.jpg

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