长链非编码 RNA/环状非编码 RNA-miRNA-mRNA 轴在心血管疾病中的作用。
Long noncoding RNA/circular noncoding RNA-miRNA-mRNA axes in cardiovascular diseases.
机构信息
Department of Gastroenterology, The Second Hospital of Jilin University, 218 Ziqiang Road, Changchun 130041, China.
Department of Cardiology, The Second Hospital of Jilin University, 218 Ziqiang Road, Changchun 130041, China.
出版信息
Life Sci. 2019 Sep 15;233:116440. doi: 10.1016/j.lfs.2019.04.066. Epub 2019 Apr 30.
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Non-coding RNAs including long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and microRNAs (miRNAs) have been reported to participate in pathological developments of CVDs through various mechanisms. Among them, the networks among lncRNAs/circRNAs, miRNAs, and mRNAs have recently attracted attention. Understanding the molecular mechanism could aid the discovery of therapeutic targets or strategies in CVDs including atherosclerosis, myocardial infarction (MI), hypertrophy, heart failure (HF) and cardiomyopathy. In this review, we summarize the latest research involving the lncRNA/circRNA-miRNA-mRNA axis in CVDs, with emphasis on the molecular mechanism.
心血管疾病（CVDs）是全球范围内的主要死亡原因。非编码 RNA 包括长非编码 RNA（lncRNAs）、环状 RNA（circRNAs）和 microRNAs（miRNAs），据报道，它们通过多种机制参与 CVDs 的病理发展。其中，lncRNAs/circRNAs、miRNAs 和 mRNAs 之间的网络最近引起了关注。了解分子机制有助于发现 CVDs 包括动脉粥样硬化、心肌梗死（MI）、肥大、心力衰竭（HF）和心肌病的治疗靶点或策略。在这篇综述中，我们总结了涉及 CVDs 中 lncRNA/circRNA-miRNA-mRNA 轴的最新研究，重点介绍了分子机制。
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