Department of Anesthesiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province 650032, PR China.
Department of Anesthesiology, Yan'an Hospital of Kunming City, Kunming Medical University, Kunming, Yunnan Province 650051, PR China.
Epigenomics. 2018 May;10(5):661-671. doi: 10.2217/epi-2017-0176. Epub 2018 Apr 25.
Protein coding sequences account for around 3% of the human genome, the rest are noncoding RNA (ncRNA) including long ncRNA (lncRNA) and miRNA. Accumulating evidence indicates that lncRNAs and miRNAs are candidate biomarkers for diagnosis, prognosis and therapy of cardiovascular diseases. The lncRNAs act as sponge-like effects on numerous miRNAs, subsequently regulating miRNAs and their targets, mRNA functions. The role of lncRNA-miRNA-mRNA axis in pathogenesis of cardiovascular diseases has been recently reported and highlighted. Herein, this review discusses emerging roles of lncRNA-miRNA-mRNA axis in cardiovascular pathophysiology and regulation, with a novel focus on cardioprotective network activities of the two subgroup ncRNAs.
蛋白质编码序列约占人类基因组的 3%，其余为非编码 RNA（ncRNA），包括长 ncRNA（lncRNA）和 miRNA。越来越多的证据表明，lncRNA 和 miRNA 是心血管疾病诊断、预后和治疗的候选生物标志物。lncRNA 对许多 miRNA 具有海绵样效应，进而调节 miRNA 及其靶标、mRNA 功能。lncRNA-miRNA-mRNA 轴在心血管疾病发病机制中的作用最近已经被报道并得到强调。在此，本综述讨论了 lncRNA-miRNA-mRNA 轴在心血管病理生理学和调节中的新兴作用，重点介绍了这两组 ncRNA 的心脏保护网络活性。
