脊髓损伤后 Froin 综合征。
Froin Syndrome After Spinal Cord Injury.
机构信息
Department of Neurosurgery, University Hospitals, Leuven, Belgium.
Department of Neurology, University Hospitals, Leuven, Belgium.
出版信息
World Neurosurg. 2019 Jul;127:490-491. doi: 10.1016/j.wneu.2019.04.198. Epub 2019 May 21.
BACKGROUND
Froin syndrome is characterized by xanthochromia and hypercoagulability of the cerebrospinal fluid (CSF) due to elevated protein levels. This entity results from blockage of the spinal canal by a mass lesion leading to an isolated caudal CSF space.
CASE DESCRIPTION
A 48-year-old male, who developed spasticity after a C6 spinal cord injury (SCI) 20 years earlier, presented with subobstruction of his intrathecal baclofen pump. A catheter access port aspiration revealed an extremely high protein concentration (38 g/L) with no signs of infection. Froin syndrome was confirmed when magnetic resonance imaging showed a complete obstruction of the spinal canal at the SCI level.
CONCLUSIONS
We report the first case of Froin syndrome after SCI. Froin syndrome can impact intrathecal drug delivery and CSF diagnostics.
背景
弗洛因综合征的特征是由于蛋白质水平升高导致脑脊液（CSF）呈黄色和高凝状态。这种情况是由于椎管内的肿块阻塞导致脑脊液尾部空间孤立而引起的。
病例描述
一名 48 岁男性，20 年前因 C6 脊髓损伤（SCI）出现痉挛，此次出现鞘内巴氯芬泵部分阻塞。导管接入端口抽吸显示极高的蛋白浓度（38 g/L），无感染迹象。当磁共振成像显示 SCI 水平的椎管完全阻塞时，确认了弗洛因综合征。
结论
我们报告了首例 SCI 后的弗洛因综合征病例。弗洛因综合征会影响鞘内药物输送和 CSF 诊断。
Zotero 插件