LSCDFS-MKL: A multiple kernel based method for lung squamous cell carcinomas disease-free survival prediction with pathological and genomic data.

Lung squamous cell carcinoma (SCC) is a fatal disease in both male and female, for which current treatments are inadequate. Surgical resection is regarded as the cornerstone of treatment for patients with lung SCC, but even for the same stage patients, the wide spectrum of disease-free survival (DFS) times exits. Therefore, how to improve the DFS prediction performance of lung SCC becomes one major research area. In this study, we proposed a novel method called LSCDFS-MKL, which was on the basis of multiple kernel learning to predict DFS of lung SCC. In LSCDFS-MKL, we first efficiently integrated pathological images and genomic data (copy number aberration, gene expression, protein expression) from lung SCC. The results of LSCDFS-MKL between different types of data show that the features extracted from pathological images play an important role in DFS prediction of lung SCC. Then we compared our method LSCDFS-MKL with other existing methods and performance analysis indicates that LSCDFS-MKL has a significantly better performance than other prediction methods. After that, we applied the proposed method on different stage stratums and the performance demonstrates that LSCDFS-MKL remains efficient in DFS prediction of lung SCC patients. Finally, we performed LSCDFS-MKL on an independent validation dataset and the accuracy of DFS prediction achieves 100%, which is promising.