Kalivas P W, Stanley D, Prange A J
Neuropharmacology. 1987 Jan;26(1):33-8. doi: 10.1016/0028-3908(87)90041-4.
The involvement of the mesolimbic dopamine (DA) system in the excitatory behavioral effects of thyrotropin-releasing hormone (TRH) has been a controversial topic. In this study TRH was injected into the nucleus accumbens, lateral ventricles or ventral tegmental area and changes in spontaneous motor activity and metabolism of DA in the nucleus accumbens and striatum measured. Injection of TRH into all three areas of the brain produced an increase in photocell counts of locomotor activity and, in the nucleus accumbens, a significant decrease in photocell counts of rearing was measured. Injection of TRH into the nucleus accumbens caused a marked increase in metabolism of DA in both the nucleus accumbens and striatum. A smaller increase in metabolism of DA was also observed after injection of TRH into the lateral ventricles, but no significant change was found after intra-ventral tegmental administration of TRH. These data indicate that while TRH probably acts in the nucleus accumbens to enhance the metabolism of DA, and presumably release of DA, the excitatory behavioral effect of TRH is only partially mediated by this dopaminergic mechanism.
中脑边缘多巴胺（DA）系统参与促甲状腺激素释放激素（TRH）的兴奋性行为效应一直是一个有争议的话题。在本研究中，将TRH注入伏隔核、侧脑室或腹侧被盖区，并测量伏隔核和纹状体中自发运动活动和DA代谢的变化。将TRH注入大脑的所有三个区域均使运动活动的光电管计数增加，并且在伏隔核中，测量到竖毛的光电管计数显著减少。将TRH注入伏隔核导致伏隔核和纹状体中DA的代谢显著增加。将TRH注入侧脑室后也观察到DA代谢有较小程度的增加，但在腹侧被盖区注射TRH后未发现显著变化。这些数据表明，虽然TRH可能在伏隔核中起作用以增强DA的代谢，并推测释放DA，但TRH的兴奋性行为效应仅部分由这种多巴胺能机制介导。
