Kloecking H P, Hoffmann A, Markwardt F
Pathol Biol (Paris). 1987 Feb;35(2 Pt 2):231-2.
SIN-1--a pharmacologically active metabolite of the vasodilating agent molsidomine--caused an increase in plasminogen activator release of about 50 per cent at a final concentration of 10(-7) mol/l on perfusion of isolated pig ears. An increase in SIN-1 concentration did not produce a further increase in activator release. The released activator is of the tissue-type. After repeated perfusion of the isolated pig ear with SIN-1 no further significant increase in plasminogen activator release occurred.
SIN - 1（一种血管舒张剂吗多明的药理活性代谢产物）在终浓度为10⁻⁷mol/L时，对离体猪耳进行灌注，可使纤溶酶原激活物释放增加约50%。SIN - 1浓度升高并未使激活物释放进一步增加。所释放的激活物为组织型。用SIN - 1对离体猪耳进行反复灌注后，纤溶酶原激活物释放未再出现显著增加。
