基础动物研究对神经精神疾病的至关重要性。 - Suppr | 超能文献

文献检索
文档翻译
深度研究
学术资讯

Zotero 插件

邀请有礼
套餐&价格
历史记录

应用&插件

Zotero 插件浏览器插件 Mac 客户端 Windows 客户端微信小程序

定价

高级版会员购买积分包购买API积分包

服务

文献检索文档翻译深度研究 API 文档 MCP 服务

关于我们

关于 Suppr 公司介绍联系我们用户协议隐私条款

关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1

The critical importance of basic animal research for neuropsychiatric disorders.基础动物研究对神经精神疾病的至关重要性。

Neuropsychopharmacology. 2019 Jul;44(8):1349-1353. doi: 10.1038/s41386-019-0405-9. Epub 2019 May 2.

2

Revitalizing psychiatric therapeutics.振兴精神科治疗学。

Neuropsychopharmacology. 2014 Jan;39(1):220-9. doi: 10.1038/npp.2013.181.

3

New dimensions in the use of rodent behavioral tests for novel drug discovery and development.用于新型药物发现与开发的啮齿动物行为测试应用的新维度。

Expert Opin Drug Discov. 2016;11(4):343-53. doi: 10.1517/17460441.2016.1153624. Epub 2016 Mar 7.

4

The genetic and epigenetic landscape for CNS drug discovery targeting cross-diagnostic behavioral domains.针对跨诊断行为领域的中枢神经系统药物发现的遗传和表观遗传格局。

Eur J Pharmacol. 2015 Apr 15;753:135-9. doi: 10.1016/j.ejphar.2014.07.043. Epub 2014 Aug 5.

5

Advancing drug discovery for neuropsychiatric disorders using patient-specific stem cell models.利用患者特异性干细胞模型推进神经精神疾病的药物研发。

Mol Cell Neurosci. 2016 Jun;73:104-15. doi: 10.1016/j.mcn.2016.01.011. Epub 2016 Jan 28.

6

Role of murine models in psychiatric illness drug discovery: a dimensional view.在精神疾病药物研发中，鼠类模型的作用：一个维度的视角。

Expert Opin Drug Discov. 2013 Jul;8(7):865-77. doi: 10.1517/17460441.2013.797959. Epub 2013 May 8.

7

Three paths to drug discovery in psychiatry.精神病学中药物发现的三条途径。

Am J Psychiatry. 2015 May;172(5):412-4. doi: 10.1176/appi.ajp.2014.14070858.

8

Commentary: obstacles to the discovery of medicines for psychiatric disorders in modern times.评论：现代精神疾病药物发现的障碍

CNS Neurol Disord Drug Targets. 2015;14(1):4-6. doi: 10.2174/1871527314666150130154757.

9

How promising is neuroactive steroid drug discovery?

Expert Opin Drug Discov. 2018 Nov;13(11):993-995. doi: 10.1080/17460441.2018.1518974. Epub 2018 Sep 17.

10

How can preclinical cognitive research further neuropsychiatric drug discovery? Chances and challenges.临床前认知研究如何进一步推动神经精神药物的发现？机遇与挑战。

Expert Opin Drug Discov. 2020 Jun;15(6):659-670. doi: 10.1080/17460441.2020.1739645. Epub 2020 Mar 18.

引用本文的文献

1

Tracking conditioned fear in pair-housed mice using deep learning and real-time cue delivery.使用深度学习和实时线索传递追踪成对饲养小鼠的条件性恐惧。

Neurobiol Stress. 2025 Jun 19;37:100742. doi: 10.1016/j.ynstr.2025.100742. eCollection 2025 Jul.

2

Recommendations, guidelines, and best practice for the use of human induced pluripotent stem cells for neuropharmacological studies of neuropsychiatric disorders.关于使用人类诱导多能干细胞进行神经精神疾病神经药理学研究的建议、指南和最佳实践。

Neurosci Appl. 2023 Mar 20;2:101125. doi: 10.1016/j.nsa.2023.101125. eCollection 2023.

3

Tracking Conditioned Fear in Pair-Housed Mice Using Deep Learning and Real-Time Cue Delivery.

本文引用的文献

1

Treatment resistant depression: A multi-scale, systems biology approach.治疗抵抗性抑郁症：一种多尺度、系统生物学方法。

Neurosci Biobehav Rev. 2018 Jan;84:272-288. doi: 10.1016/j.neubiorev.2017.08.019. Epub 2017 Aug 30.

2

The chronic mild stress (CMS) model of depression: History, evaluation and usage.抑郁症的慢性轻度应激（CMS）模型：历史、评估与应用。

Neurobiol Stress. 2016 Aug 24;6:78-93. doi: 10.1016/j.ynstr.2016.08.002. eCollection 2017 Feb.

3

Resting-state connectivity biomarkers define neurophysiological subtypes of depression.

利用深度学习和实时线索传递追踪成对饲养小鼠的条件性恐惧。

bioRxiv. 2025 May 15:2025.05.10.653260. doi: 10.1101/2025.05.10.653260.

4

Therapeutic Targeting of the α7 Nicotinic Receptor: Challenges and Prospects for Cognitive Improvement in Alzheimer's and Schizophrenia.α7烟碱型受体的治疗靶点：阿尔茨海默病和精神分裂症认知改善的挑战与前景

Basic Clin Pharmacol Toxicol. 2025 Jul;137(1):e70061. doi: 10.1111/bcpt.70061.

5

Ketamine Evokes Acute Behavioral Effects Via μ Opioid Receptor-Expressing Neurons of the Central Amygdala.氯胺酮通过中央杏仁核中表达μ阿片受体的神经元诱发急性行为效应。

Biol Psychiatry. 2025 May 5. doi: 10.1016/j.biopsych.2025.04.020.

6

Illuminating the impact of stress: In vivo approaches to track stress-related neural adaptations.揭示压力的影响：追踪与压力相关神经适应性的体内研究方法。

Neurobiol Stress. 2025 Feb 7;35:100712. doi: 10.1016/j.ynstr.2025.100712. eCollection 2025 Mar.

7

The number of conspecific alarm substance donors notably influences the behavioural responses of zebrafish subjected to a traumatic stress procedure.同种警报物质供体的数量显著影响经历创伤应激程序的斑马鱼的行为反应。

Fish Physiol Biochem. 2025 Feb 26;51(2):55. doi: 10.1007/s10695-025-01468-0.

8

Evaluation of Prenatal Transportation Stress on DNA Methylation (DNAm) and Gene Expression in the Hypothalamic-Pituitary-Adrenal (HPA) Axis Tissues of Mature Brahman Cows.产前运输应激对成年婆罗门牛下丘脑-垂体-肾上腺（HPA）轴组织中DNA甲基化（DNAm）和基因表达的影响评估

Genes (Basel). 2025 Feb 4;16(2):191. doi: 10.3390/genes16020191.

9

Long-term tracking of social structure in groups of rats.长期追踪大鼠群体中的社会结构。

Sci Rep. 2024 Oct 1;14(1):22857. doi: 10.1038/s41598-024-72437-5.

10

The Influence of Cecal Microbiota Transplantation on Chicken Injurious Behavior: Perspective in Human Neuropsychiatric Research.盲肠微生物群移植对鸡伤害行为的影响：人类神经精神疾病研究的视角。

Biomolecules. 2024 Aug 16;14(8):1017. doi: 10.3390/biom14081017.

静息态连接生物标志物定义了抑郁症的神经生理亚型。

Nat Med. 2017 Jan;23(1):28-38. doi: 10.1038/nm.4246. Epub 2016 Dec 5.

4

The promises and challenges of human brain organoids as models of neuropsychiatric disease.人类脑类器官作为神经精神疾病模型的前景与挑战。

Nat Med. 2016 Nov;22(11):1220-1228. doi: 10.1038/nm.4214. Epub 2016 Oct 26.

5

Using Neuroscience to Help Understand Fear and Anxiety: A Two-System Framework.利用神经科学理解恐惧和焦虑：双系统框架。

Am J Psychiatry. 2016 Nov 1;173(11):1083-1093. doi: 10.1176/appi.ajp.2016.16030353. Epub 2016 Sep 9.

6

Animal models of neuropsychiatric disorders.神经精神疾病的动物模型。

Nat Neurosci. 2010 Oct;13(10):1161-9. doi: 10.1038/nn.2647. Epub 2010 Sep 27.

7

Opportunities and challenges of psychiatric drug discovery: roles for scientists in academic, industry, and government settings.精神科药物研发的机遇与挑战：学术、产业及政府机构中科学家的角色

Neuropsychopharmacology. 2008 Aug;33(9):2048-60. doi: 10.1038/sj.npp.1301638. Epub 2008 Jan 23.

8

The neurobiology of depression: inroads to treatment and new drug discovery.抑郁症的神经生物学：治疗途径与新药研发

J Clin Psychiatry. 2005;66 Suppl 7:5-13.

9

Stress and disease.压力与疾病。

Science. 1955 Oct 7;122(3171):625-31. doi: 10.1126/science.122.3171.625.

10

Functional antagonists at the NMDA receptor complex exhibit antidepressant actions.N-甲基-D-天冬氨酸（NMDA）受体复合物的功能性拮抗剂具有抗抑郁作用。

Eur J Pharmacol. 1990 Aug 21;185(1):1-10. doi: 10.1016/0014-2999(90)90204-j.

基础动物研究对神经精神疾病的至关重要性。 - Suppr | 超能文献

The critical importance of basic animal research for neuropsychiatric disorders.

作者信息

Bale Tracy L, Abel Ted, Akil Huda, Carlezon William A, Moghaddam Bita, Nestler Eric J, Ressler Kerry J, Thompson Scott M

机构信息

Departments of Pharmacology and Psychiatry, Center for Epigenetic Research in Child Health and Brain Development, University of Maryland School of Medicine, Baltimore, MD, USA.

Department of Pharmacology and Iowa Neuroscience Institute, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

出版信息

Neuropsychopharmacology. 2019 Jul;44(8):1349-1353. doi: 10.1038/s41386-019-0405-9. Epub 2019 May 2.

DOI:10.1038/s41386-019-0405-9

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6784904/

Abstract

摘要